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Structures of different linker groups used in ADCs. (a) A cleavable hydrazone linker and disulphide trigger as used in Mylotarg®; (b) an MC–Val–Cit–PABC linker, combining the non-cleavable MC and dipeptide cleavable Val–Cit linkers with a PABC spacer, as used in Adcetris®; (c) a non-cleavable MCC linker as used in Kadcyla®.
