Table 2.
Effect of modulation of the expression of STIM and Orai isoforms on the migration of different cell lines.
| Cell Lines | Method | Result | Ref. |
|---|---|---|---|
| Human embryonic kidney cells (HEK293) | STIM1/Orai1 knockdown | Reduced migration | [92] |
| Vascular smooth muscle cells (VSMCs) | STIM1/STIM2/Orai1/Orai2/Orai3 knockdown | STIM1/Orai1 reduced migration No effect for STIM2/Orai2/Orai3 |
[93,94] |
| Mouse embryonic fibroblasts (MEF) | STIM1 knockout | Enhanced migration | [95] |
| STIM1 knockdown | Reduced invasion | [96] | |
| Human umbilical vein endothelial cells (HUVEC) | STIM1 knockdown | Enhanced migration | [24] |
| STIM1 overexpression | Decreased migration | ||
| Primary human bronchial smooth muscle cells | STIM1/STIM2/Orai1 knockdown | STIM1/Orai1 reduced migration STIM2 no effect |
[97] |