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. 2021 Jan 23;29(3-4):323–330. doi: 10.1186/BF03548625

Treatment of Neonatally Aleutian Disease Virus (ADV) Infected Mink Kits with Gammaglobulin Containing Antibodies to ADV Reduces the Death Rate of Mink Kits

Behandling af nyfødte plasmacytosevirus (ADV) inficerede mink hvalpe med gammaglobulin indeholdende antistoffer mod ADV reducerer mortaliteten af mink hvalpene

Bent Aasted 18,28,✉, Seren Alexandersen 18,28, Mogens Hansen 18,28
PMCID: PMC8161657  PMID: 2476006

Abstract

Aleutian disease virus (ADV) can cause pneumonitis in newborn kits up to 3 weeks old. In many cases the pneumonitis is fatal, but can be reduced by treatment with antibodies to ADV. The present report describes antibody therapy in both experimentally infected mink kits and in mink kits from a farm, where an ADV epidemic developed during the whelping period in the spring of 1987. In both cases the antibody treatment was found to have a beneficial effect on the survival rate of the mink kits. One hundred percent survival rate was found for the experimentally infected mink kits. The most pronounced effect for the naturally infected mink was found in the wildtype mink kits, where the death rate was 9.6 % for the antibody treated group versus 16.9 % for the untreated group (p < 0.001). In general the success rate of the gammaglobulin treatment seemed to correlate with the ADV-infection level in the mink sheds. The highest success rate was found in the sheds with the highest ADV-infection level (the standard and wildtype mink), while no effect whatsoever was found for the pearl mink, which were placed in a shed with a low ADV-infection level.

Keywords: parvovirus, pneumonitis, ADV prevention, mortality.

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Acknowledgments

Mink consultant Hans Henrik Moller is acknowledged for his valuable help with mink death recordings and statistician Jesper Clausen, The Danish Fur Breeders Association, for the statistical treatment of the data. Technical help from Ms. Else Bang Larsen, Ms. Anne Friis Petersen, and Dr. Anders Cohn is greatfully acknowledged. The study was supported by the Danish Veterinary and Agricultural Research Council and the Danish Fur Breeders’ Association Research Foundation.

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