Dear Editor, we would like to share ideas on “Locally harvested Covid-19 convalescent plasma could probably help combat the geographically determined SARS-CoV-2 viral variants [1]� Raturi et al. concluded that “using COVID-19 convalescent plasma [CCP] harvested from the locally recovered… [1]�. Indeed, the usefulness of convalescent plasma therapy is widely discussed. Theoretically, antibody-pathogen interaction is the basic therapeutic interaction. If a mutant does not occur at antibody binding site, there will not be any effect on therapeutic interaction. Nevertheless, a recent study showed that there might be distinct SARS-CoV-2 antibody reactivity patterns in convalescent plasma [2]. It is interesting to have a further study on background SARS-CoV-2 antibody reactivity pattern and therapeutic response to convalescent plasma in cases with SARS-CoV-2 viral variants.
Disclosure of interest
The authors declare that they have no competing interest.
References
- 1.Raturi M., Kusum A., Kala M., Mittal G., Sharma A., Bansal N. Locally harvested Covid-19 convalescent plasma could probably help combat the geographically determined SARS-CoV-2 viral variants. Transfus Clin Biol. 2021 doi: 10.1016/j.tracli.2021.05.003. [S1246-7820(21)00073-2 Online ahead of print] [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Assis R., Jain A., Nakajima R., Jasinskas A., Khan S., Davies H., et al. Distinct SARS-CoV-2 antibody reactivity patterns in coronavirus convalescent plasma revealed by a coronavirus antigen microarray. Sci Rep. 2021;11:7554. doi: 10.1038/s41598-021-87137-7. [DOI] [PMC free article] [PubMed] [Google Scholar]