Figure 4.

Protective efficacy following SARS-CoV-2 challenge

Rhesus macaques were challenged by the intranasal and intratracheal routes with 1.0 × 10⁵ TCID50 SARS-CoV-2.

(A) Peak log₁₀ sgRNA copies/mL (limit of quantification 50 copies/mL) were assessed in BAL following challenge.

(B) Peak log₁₀ sgRNA copies/swab (limit of quantification 50 copies/swab) were assessed in NSs following challenge. Horizontal lines reflect geometric mean values. Solid black circles indicate animals that showed no virus in BAL and NS following challenge; open black circles indicate animals that showed virus in NSs, but not BAL, following challenge; and open red circles indicate animals that show virus in both BAL and NSs following challenge.