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miR-146a plays a relevant role in thrombo-inflammation after sterile and non-sterile stresses. Low miR-146a levels promote an aging phenotype in neutrophils (CD62low CD11bhigh Cxcr4high Tlr4high) which primes these cells. Upon sterile or non-sterile stimuli, primed neutrophils would be more prone to NETosis leading to a thrombo-inflammatory process. MiR-146a: microRNA- 146a; LPS: lipopolysaccharide; CAP: community-acquired pneumonia.
