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. 2021 May 5;594(7861):77–81. doi: 10.1038/s41586-021-03519-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — The distance between adjacent ILS segments (inter-ILS) (500-bp resolution) was calculated and the distribution was compared to a simulated expectation based on a random distribution. The analysis reveals a bimodal (and possibly an emerging trimodal) pattern in which a distinct subset of ILS segments are clustered (that is, clustered ILS sites). Four different topologies were considered. a, A (orangutan, (((bonobo, chimpanzee), gorilla), human)) ILS topology in which 31.58% of inter-ILS is clustered is shown. b, A (orangutan, ((bonobo, chimpanzee), (gorilla, human))) ILS topology in which 33.5% is clustered is shown. c, A (orangutan, (((bonobo, human), chimpanzee), gorilla)) ILS topology in which 8.14% is clustered is shown. d, A (orangutan, ((bonobo, (chimpanzee, human)), gorilla)) ILS topology in which 9.89% of sites is clustered is shown. e, An example of a cluster of human–bonobo (red triangles) and human–chimpanzee (blue triangles) ILS corresponding to a group of genes. A four-species alignment of one exon from EGF (exon 5) is shown with a nominal signal of positive selection.