Table 2.

Selected factors of mouse β-cell SASP signature

Target	Name	Role in senescence, inflammation, and β-cell function
GSTP1	Glutathione S-transferase P	Cell proliferation inhibitor and p53 target (50,51)
GDF15	Growth differentiation factor 15	SASP factor and involved in aging and mitochondrial dysfunction (30,43,52,53)
DUSP3	Dual specificity protein phosphatase 3	Regulates cell proliferation and DNA damage response (54)
HSP90AA1	Heat shock protein 90α family class A member 1	Senolytic target, released by β-cells stressed by inflammation (55–57)
ING1	Inhibitor of growth protein 1	Regulator of senescence (58)
KPNB1	Karyopherin subunit β1	Mediates activity of inflammatory transcription factors (59)

Six top mouse β-cell SASP targets with references to previous publications describing their roles in senescence, inflammation, and β-cell function.