Table 2.
Target | Name | Role in senescence, inflammation, and β-cell function |
---|---|---|
GSTP1 | Glutathione S-transferase P | Cell proliferation inhibitor and p53 target (50,51) |
GDF15 | Growth differentiation factor 15 | SASP factor and involved in aging and mitochondrial dysfunction (30,43,52,53) |
DUSP3 | Dual specificity protein phosphatase 3 | Regulates cell proliferation and DNA damage response (54) |
HSP90AA1 | Heat shock protein 90α family class A member 1 | Senolytic target, released by β-cells stressed by inflammation (55–57) |
ING1 | Inhibitor of growth protein 1 | Regulator of senescence (58) |
KPNB1 | Karyopherin subunit β1 | Mediates activity of inflammatory transcription factors (59) |
Six top mouse β-cell SASP targets with references to previous publications describing their roles in senescence, inflammation, and β-cell function.