Table 3.
Electrophysiological properties of excitatory CA1 pyramidal neurons from heterozygous (Scn1aKT/+) and control (Scn1a+/+) mice
| Properties | Scn1a+/+ | Scn1aKT/+ | p value |
|---|---|---|---|
| Cells # (animals #) | 12 (8) | 17 (9) | |
| Capacitance (pF) | 27.71 ± 1.93 | 31.77 ± 3.23 | 0.340 |
| Input resistance (MΩ) | 182.04 ± 20.59 | 187.62 ± 13.58 | 0.815 |
| Resting potential (mV) | −65.16 ± 1.01 | −65.09 ± 0.69 | 0.947 |
| AP threshold (mV) | −42.99 ± 1.36 | −43.29 ± 1.54 | 0.891 |
| AP amplitude (mV) | 77.27 ± 3.30 | 69.28 ± 3.90 | 0.152 |
| Spike frequency adaptation (ISI1/ISIn) | 0.234 ± 0.04 | 0.384 ± 0.07 | 0.085 |
Statistical comparisons were made with two-tailed unpaired Student’s t test