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. 2021 Apr 13;8(2):ENEURO.0499-20.2021. doi: 10.1523/ENEURO.0499-20.2021

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Copyright © 2021 Yamanaka et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Reconstructed 3D images of deconvoluted z-scanned confocal images of immunoreactive structures for synaptophysin (green), MAP-2 (red), and tL1-CAM (blue) in the dorsal horn of control and SNI model rats. A, 3D images of synaptic terminals and dendrites (synaptophysin-ir and MAP-2-ir). Synaptophysin and MAP-2 contacts are represented as yellow spots on MAP-2-ir in the middle panels. The contacts in this space are represented as yellow particles in the panels in the lowest row. B, 3D images of synaptic terminals (synaptophysin-ir) and tL1-CAM-positive structures. Synaptophysin-ir and tL1-CAM-ir contacts are shown in light blue in tL1-CAM-ir, and these contacts are represented as particles in the lowest panels. C, Spots of synaptic terminals (synaptophysin-ir) in the dorsal horn of SNI and control rats are represented as green particles. D, Quantification of the total number of contact spots (synaptophysin/MAP-2, synaptophysin/tL1-CAM) and synaptophysin-ir structures in the dorsal horn (1764.0 μm² × 5.0 μm in scope × depth, four positions per animal, each model n = 4); #p < 0.05 versus control. Scale bar: 10 μm.