Table 3.

Correlation between the average severity of ocular discomfort over the last week and signs of dry eye disease, the Ocular Surface Disease Index (OSDI) scores, SF-36 scores, interference scores on the Brief Ocular Discomfort Index , over time

	Baseline (N=535)				6 Months (N=481)				12 Months (N=488)
Characteristic	N	Mean(SD)^a	r_s	P	N	Mean(SD)^a	r_s	P	N	Mean(SD)^a	r_s	P
Signs
Conjunctival staining score	535	2.9 (1.4)	0.04	0.36	481	2.6 (1.5)	0.04	0.41	488	2.5 (1.5)	0.10	0.02
Corneal staining score	535	3.8 (2.8)	0.12	0.006	481	3.3 (2.7)	0.11	0.02	488	3.2 (2.7)	0.06	0.17
Tear break-up time (seconds)	535	3.1 (1.6)	−0.05	0.25	481	3.7 (2.5)	−0.08	0.08	488	3.8 (2.3)	−0.07	0.13
Schirmer test (mm)	535	9.6 (6.7)	−0.10	0.02	477	10.0 (6.6)	−0.01	0.84	484	9.9 (6.4)	−0.04	0.39
OSDI (lower is better)
Total score	535	42.1 (15.5)	0.47	<0.001	481	32.2 (19.1)	0.61	<0.001	488	30.5 (18.6)	0.67	<0.001
Vision-related function	535	35.2 (19.2)	0.23	<0.001	481	26.5 (21.1)	0.47	<0.001	488	24.7 (20.7)	0.53	<0.001
Ocular symptoms	535	45.1 (19.1)	0.44	<0.001	481	34.7 (21.8)	0.56	<0.001	488	32.9 (22.1)	0.57	<0.001
Environmental triggers	529	52.6 (26.8)	0.38	<0.001	475	41.1 (29.6)	0.50	<0.001	481	39.6 (29.0)	0.51	<0.001
SF-36 (higher is better)
Summary: Physical Health	535	47.5 (9.7)	−0.10	0.02	478	47.7 (10.3)	−0.19	<0.001	486	47.7 (10.2)	−0.18	<0.001
Physical Functioning	535	48.3 (9.6)	−0.06	0.13	478	48.4 (9.7)	−0.12	0.01	487	48.4 (9.7)	−0.17	<0.001
Role Limitations-Physical Health	535	47.5 (9.6)	−0.14	0.001	479	47.4 (10.0)	−0.22	<0.001	487	48.0 (10.0)	−0.23	<0.001
Bodily Pain	535	47.3 (9.7)	−0.10	0.02	479	47.3 (10.1)	−0.28	<0.001	487	47.5 (9.9)	−0.21	<0.001
General Health Perceptions	535	52.0 (10.2)	−0.13	0.003	479	51.5 (10.7)	−0.16	<0.001	487	51.5 (10.4)	−0.13	0.003
Summary: Mental Health	535	52.3 (9.4)	−0.11	0.01	479	51.7 (9.8)	−0.19	<0.001	486	52.2 (9.0)	−0.18	<0.001
Vitality	535	51.3 (9.8)	−0.12	0.005	479	51.1 (10.3)	−0.21	<0.001	486	51.3 (9.7)	−0.21	<0.001
Social Functioning	535	49.6 (9.6)	−0.12	0.006	479	49.6 (9.9)	−0.24	<0.001	487	49.6 (9.4)	−0.18	<0.001
Role Limitations-Emotional Problems	535	50.1 (9.3)	−0.12	0.007	479	49.6 (9.6)	−0.16	<0.001	487	50.3 (9.3)	−0.20	<0.001
Mental Health	535	52.4 (8.6)	−0.13	0.004	479	51.6 (9.2)	−0.22	<0.001	486	52.2 (8.6)	−0.20	<0.001
Brief Ocular Discomfort Index
Interference with activities of daily living (lower is better)
General activity	535	33.1 (23.1)	0.60	<0.001	481	25.2 (24.7)	0.63	<0.001	488	22.2 (24.2)	0.65	<0.001
Mood	535	28.6 (24.1)	0.52	<0.001	481	21.9 (23.7)	0.55	<0.001	488	18.4 (22.1)	0.56	<0.001
Walking ability	534	18.2 (22.2)	0.37	<0.001	481	13.7 (21.4)	0.39	<0.001	488	12.2 (19.6)	0.44	<0.001
Normal work	535	29.9 (23.7)	0.51	<0.001	481	21.5 (23.3)	0.56	<0.001	488	19.3 (22.5)	0.57	<0.001
Relations with other people	535	17.1 (21.0)	0.40	<0.001	481	12.6 (19.9)	0.44	<0.001	488	11.7 (19.4)	0.48	<0.001
Sleep	535	20.0 (23.8)	0.40	<0.001	481	15.3 (20.9)	0.44	<0.001	488	13.3 (20.4)	0.40	<0.001
Enjoyment of life	535	25.7 (23.5)	0.51	<0.001	481	19.3 (22.4)	0.52	<0.001	488	17.4 (22.1)	0.56	<0.001
Relief from treatment (higher is better)	534	38.5 (27.5)	−0.02	0.60	479	44.2 (31.3)	−0.08	0.07	483	45.8 (32.0)	−0.02	0.61

SD is standard deviation