The authors and journal were simultaneously informed of potential image duplications in the original paper in July 2020. The authors found an image processing error that affected Figures 3, 7, and EV1, which resulted in consecutive slices from the same sample being mislabeled and misrepresented as data deriving from different mice of different treatment groups and genotypes. The authors state that this happened during the repeat and staining process and in the preparation of representative images. The authors voluntarily conducted repeat experiments to confirm the conclusions of the affected figures.
Figure 3.
Figure 7.
Figure EV1.
The journal determined that the conclusions derived from the affected figures were supported by independent experimental results within the paper and recommended an evaluation by an independent institutional investigation.
In December 2020, an institutional committee compared the data from the original paper with the repeated experimentation. The committee found that the figures and statistics reported in the original paper were consistent with the repeated experimental data: In Figure EV1E‐F, the original data showed a dosage‐dependent effect of dietary succinate on MyHC‐I levels, which is not fully supported by the repeat data. The repeat data conclude that while there is a significant increase in MyHC‐I percentage in response to 0.5% dietary succinate compared with the control, it is not dependent on the dosage. The authors withdraw the phrase “dose‐dependently” in the following sentence:
“Consistently, we found that succinate dose‐dependently increased MyHC‐I but not MyHC‐IIb protein expression in soleus, suggesting an increased proportion of slow‐twitch fiber (Figs EV1E‐F)”.
The journal agrees with the authors’ decision to withdraw Figures 3C‐D, 7M‐N, and EV1E‐N and to publish the repeat data with this partial withdrawal notice.
All authors agree with this partial withdrawal and apologize for the inconvenience their mistake caused.
Supporting information
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Source Data for Figure 3
Correction to: EMBO Reports (2019) 20: e47892. DOI 10.15252/embr.201947892 | Published online 18 July 2019
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Supplementary Materials
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Source Data for Figure 3