Correction to: Blood Cancer Journal
10.1038/s41408-021-00444-0 published online 4 March 2021
Table 1 in this article was published with some comments in the original version. We apologize for the mistake. This has been corrected below:
Table 1.
Demographic and laboratory characteristics of 4118 MASS-FIX positive patients, stratified by non-LC N-glycosylated (3897) and LC N-glycosylated (221) subgroups.
| Total MASS-FIX Positive | No LC N-glycosylation | LC N-glycosylation | P value | |
|---|---|---|---|---|
| Men | 2476 (60) | 2335 (60) | 141 (64) | 0.25 |
| Age at diagnosis [median years (IQR)] | 67 (59–74) | 67 (59–74) | 69 (59–74) | 0.77 |
| Follow-up from diagnosis [median years (IQR)] | 1.5 (0.5–5.1) | 1.5 (0.5–5.1) | 1.6 (0.5–5.2) | 0.57 |
| Time from diagnosis to MASS-FIX [median months (IQR)] | 3.5 (0.1–50.7) | 3.3 (0.1–50.5) | 5.0 (0.1–55.3) | 0.09 |
| Treated prior to MASS-FIX | 1299 (32) | 1221 (31) | 78 (35) | 0.22 |
| Free light chains | ||||
| Increased FLC ratio (kappa) | 1443 (39) | 1333 (38) | 110 (55) | <0.001 |
| Decreased FLC ratio (lambda) | 557 (15) | 536 (15) | 21 (10) | 0.06 |
| Normal FLC ratio | 1681 (46) | 1611 (46) | 70 (35) | |
| Serum protein electrophoresis | ||||
| Quantifiable M-spike | 1671 (41) | 1538 (39) | 133 (60) | 0.18(78) |
| MASS-FIX characteristics | ||||
| IgG isotypea | 2575 (63) | 2436 (63) | 139 (63) | 0.91 |
| IgA isotypea | 703 (17) | 685 (18) | 18 (8) | <0.001 |
| IgM isotypea | 710 (17) | 655 (17) | 55 (25) | 0.002 |
| IgD/IgE isotypeb | 15 (<1) | 15 (<1) | 0 | |
| Kappa light chain restricteda | 2374 (58) | 2201 (56) | 173 (78) | <0.001 |
| Lambda light chain restricteda | 1886 (46) | 1838 (47) | 48 (22) | <0.001 |
| Free heavy chain | 2 (<1) | 2 (<1) | 0 | |
| Light chain only | 283 (7) | 272 (7) | 11 (5) | 0.25 |
| Kappa free light chain | 121 (43) | 115 (42) | 6 (55) | |
| Lambda free light chain | 162 (57) | 157 (58) | 5 (45) | |
| Monoclonal pattern | 3626 (88) | 3437 (88) | 189 (85) | 0.23 |
| Biclonal pattern | 228 (6) | 210 (5) | 18 (8) | 0.08 |
| Triclonal pattern | 7 (<1) | 4 (<1) | 3 (1) | |
Data are given as [n (%)] unless otherwise noted. IQR, interquartile range. FLC ratio was available for 3681 MASS-FIX positive patients, 3480 non-LC N-glycosylated patients, and 201 LC N-glycosylated patients. For the LC N-glycosylation subgroup, MASS-FIX categories for heavy chain isotypes, involved light chain, light chain only, and clonality are in reference to the glycosylated monoclonal protein.
Bolded p values indicate statistically significant differences between non-LC N-glycosylated and LC N-glycosylated groups.
aFor the MASS-FIX positive group and non-LC N-glycosylated subgroup, light chain restriction and overall heavy chain isotype are not mutually exclusive due to biclonality; for the LC N-glycosylation subgroup, overall heavy chain isotype is mutually exclusive, with the exception of two patients with biclonal patterns and LC N-glycosylation of both clones (both patients were IgM kappa and IgG kappa).
bMASS-FIX is not set up to detect monoclonal IgD/IgE. Light chains detected by MASS-FIX and samples reflexed to standard, gel-based immunofixation.
The original article has been updated.