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Acta Veterinaria Scandinavica logoLink to Acta Veterinaria Scandinavica
. 1987 Mar 1;28(1):93–104. doi: 10.1186/BF03548260

Histomorphological Studies of the Perinatal Pig: The Unaffected Pig

Histomorfologiska studier av grisar i perinatala perioden: den normala grisen

N-E Björklund 1, J Svendsen 1,, L S Svendsen 1
PMCID: PMC8185751  PMID: 3687651

Abstract

In an attempt to further elucidate the causes of perinatal mortality in pigs, a histomorphological study of organs from normal 0.4 to 60 h old euthanized piglets and from perinatal dead/euthanized pigs belonging to different mortality groups was performed. The heart, lung, liver, kidney, spleen, thymus, pancreas, thyroid and adrenal glands were studied; all sections were examined without previous knowledge of the cause of death. Different observations in the organs were judged according to a scale of 1 to 4 where 1 = none or significant and 4 = a high degree of specific organ characteristics. The percentage of the group examined that scored 3–4 was calculated for each organ characteristic, and with the help of covariance analysis adjusted for the linear effect of total body weight (at the time of death), age, gestation length, and litter size (all pigs born, alive or dead). This first report describes the observations for the euthanized normal animals.

Keywords: histomorphological characteristics, organs, perinatal period.

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Acknowledgement

This work was supported by Grant Nos. P111 och P139 from the Swedish University of Agricultural Sciences (J. Svendsen) and by Grant No. 6000 1–5 from the National Veterinary Institute (N.-E. Björklund).

References

  1. Anderson OA. Zur Kenntnis der Morphologie der Schilddrüse. (Studies on the morphology of the thyroid gland) Arc. Anat. Entw. Anat. Abth. 1984;117:225–268. [Google Scholar]
  2. Anon.: A survey of the incidence and causes of mortality in pigs. I. Sow survey. Vet. Rec. 1959, 71, 777–786.
  3. Aron M. Indications apportées par la methode des injections hypophysaires sur le fonctionnement de la thyroide et ses tests morphologiques. (Studies on the function and morphology of the thyroid gland using injections with extracts from the hypophysis) Compte rende Soc. Biol. 1930;103:148–150. [Google Scholar]
  4. Bengtsson A-C, Svendsen J, Persson G. Jämförande undersökning av dräktiga suggor i 4 olika inhysningssystem: Beteendestudier och renhetsstudier. (Comparison of four types of housing for sows in gestation: Behaviour studies and hygiene studies) 1983. [Google Scholar]
  5. Bille N, Nielsen NC, Larsen JL, Svendsen J. Preweaning mortality in pigs. II. The perinatal period. Nord. Vet.-Med. 1974;26:294–313. [PubMed] [Google Scholar]
  6. Bischoff MB, Richter WR, Stein RJ. Ultrastructural changes in pig hepatocutes during the traditional period from late foetal to early neonatal life. J. Cell. Sei. 1969;4:381–395. doi: 10.1242/jcs.4.2.381. [DOI] [PubMed] [Google Scholar]
  7. Björklund N-E, Svendsen J, Svendsen LS. Histomorphological studies of the perinatal pig: Comparison of five mortality groups with unaffected pigs. Acta vet. scand. 1987;28:105–116. doi: 10.1186/BF03548261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bäckström L. Thesis. Acta vet. scand. 1973. Environment and animal health in piglet production. A field study of incidences and correlations; pp. 1–240. [PubMed] [Google Scholar]
  9. Coussement W, Ducatelle R, Hoorens J. Subcutaan oedeem by pasgeboren biggen. (Subcutaneous edema of the newborn pig) Vlaams Diergen. Tijdsch. 1983;52:209–219. [Google Scholar]
  10. DeRoberties E. Cytological and cytochemical basis of thyroid function. Ann. N.Y. Acad. Sci. 1949;50:317–335. [PubMed] [Google Scholar]
  11. DeRoth L, Downie HG. Evaluation of viability of neonatal swine. Canad. vet. J. 1976;17:275–279. [PMC free article] [PubMed] [Google Scholar]
  12. Dixon WJ, Brown M Editors, editors. Biomedical Computer Programs. Los Angeles: U.C.L.A. Press; 1977. pp. 1–880. [Google Scholar]
  13. Dominick MA, Carson TL. Effects of carbon monoxide exposure on pregnant sows and their fetuses. Amer. J. vet. res. 1983;44:35–40. [PubMed] [Google Scholar]
  14. Dvorák M. Adrenocortical function in foetal, neonatal and young pigs. J. Endocrinol. 1972;54:473–481. doi: 10.1677/joe.0.0540473. [DOI] [PubMed] [Google Scholar]
  15. Edwards BL. Oedema in new-born pigs. Vet. Rec. 1961;73:540–543. [Google Scholar]
  16. Friis C. Postnatal development of the pig kidney: Ultrastructure of the glomerolus and the proximal tubule. J. Anat. 1980;130:513–526. [PMC free article] [PubMed] [Google Scholar]
  17. Glastonbury JRW. Preweaning mortality in the pig. Pathological findings in piglets dying before and during partition. Austr. Vet. J. 1977;53:282–286. doi: 10.1111/j.1751-0813.1977.tb00218.x. [DOI] [PubMed] [Google Scholar]
  18. Gracey JF. Survey of pig losses. Vet. Rec. 1955;67:984–990. [Google Scholar]
  19. Hakkarainen J. Acta vet. Scand. 1975. Developmental changes of protein, RNA, DNA, lipid and glycogen in the liver, skeletal muscle and brain of the piglet; pp. 1–198. [PubMed] [Google Scholar]
  20. Jacobsen KAA. Hândbog for svinehold. (Manual in swine production) 1972. pp. 1–116. [Google Scholar]
  21. Jeppsson M, Svendsen J, Andréasson B. Beteendestudier pâ lösgäende och fixerade svinsuggor under samma skötsel-, utfodringsoch stallförhällanden. (Behaviour studies on loose and confined dry sows maintained under the same husbandry, feeding and stable conditions) 1980. [Google Scholar]
  22. Kernkamp HCH. Birth and death statistics on pigs of preweaning age. J. Amer. vet. med. Ass. 1965;145:337–340. [PubMed] [Google Scholar]
  23. Kito H, Hosada S. Triple staining for simultaneous visulization of cell types in islet of Langerhans of pancreas. Successive application of argyrophil, aldehyde-fuchsin and lead-hematoxylin stains in a single tissue section. J. Histochem. Cytochem. 1977;25:1010–1020. doi: 10.1177/25.8.70462. [DOI] [PubMed] [Google Scholar]
  24. Kühn M, Wesemeier H. Pathopenetische Schwerpunkte prä und neonataler Schädigungen beim Schwein. (Pathogenetic priorities of prenatal and neonatal damage to swine). Mh. Vet.-Med. 1984;39:551–555. [Google Scholar]
  25. LeBland CP Cit. by Platt BS, Stewart RJW: 1967.
  26. Leman AD, Knudson C, Rodeffer HE, Mueller AG. Reproductive performance of swine on 76 Illinois farms. J. Amer. vet. med. Ass. 1972;161:1248–1250. [PubMed] [Google Scholar]
  27. Miller ER, Ullrey DE, Ackerman I, Schmidt DA, Luecke RW, Hoefer JA. Swine hematology from birth to maturity. II. Erythrocyte population, size and hemoglobin concentration. J. Anim. Sei. 1961;20:890–897. doi: 10.2527/jas1961.204890x. [DOI] [PubMed] [Google Scholar]
  28. Morrill CC. Studies on baby pig mortality. IX. Some morphological observations on the newborn pig, with special reference to hypoglycemia. Amer. J. vet. Res. 1952;13:171–180. [PubMed] [Google Scholar]
  29. Nielsen NC, Christensen K, Bille N, Larsen JL. Preweaning mortality in pigs. I. Herd investigations. Nord. Vet.-Med. 1974;26:137–150. [PubMed] [Google Scholar]
  30. Platt BS, Stewart RJW. Experimental proteincaloric deficiency: Histopathological changes in the endocrine glands of pigs. J. Endocr. 1967;33:121–143. doi: 10.1677/joe.0.0380121. [DOI] [PubMed] [Google Scholar]
  31. Pomeroy RW. Interfertility and neonatal mortality in the sow. I-IV. J. agric. Sei. 1960;44:1–66. [Google Scholar]
  32. Randall GCB. The relationship between arterial blood pH and pCO2 to the viability of the newborn piglet. Canad. J. comp. Med. 1971;35:141–146. [PMC free article] [PubMed] [Google Scholar]
  33. Shapiro HA: Microscopy of human fetal lung and the diagnosis of postnatal respiration. Legal Med. Annual 1976, 39–52 (cited in Excerpta Med. 1978, 44, Sect. 5, Abs. No. 1814). [PubMed]
  34. Svendsen J, Bille N. Diseases of Swine. 5th. 1981. Reducing preweaning mortality; pp. 729–736. [Google Scholar]
  35. Svendsen J, Bengtsson A-C. Produktionssystem för smagrisuppfödning: Ätgärder för att reducera antalet klämda och trampade grisar. (Production systems for farrowing piglets: Methods for reducing the number of piglets traumatized by the sow) 1982. [Google Scholar]
  36. Svendsen LS. Acta vet. scand. 1982. Organ weights of the newborn pig. Characterization and comparison of the organ weights of pigs dying within 48 hours of birth with those of unaffected, growing pigs: Stillborn intra partum pigs, weak pigs, splaylegpigs, splayleg and weak (splayweak) pigs and traumatized pigs; pp. 1–205. [PubMed] [Google Scholar]
  37. Svendsen J, Bengtsson A-C. Produktionssystem for smâgrisuppfodning: Nâgre résultat frân 5 ârs jämförande undersökning av olika inhysningsystem för dräktiga och digivande suggor. (Housing systems in piglet production: Comparative results from 5 years of investigations into different housingsystems for sows in gestation and sows at farrowing) Konsulentavd. rapporter, Allmänt 46, Swedish Univ. Agric. Sci. 1983;16:1–16. [Google Scholar]
  38. Svendsen J, Svendsen LS, Bengtsson A-C. Reducing perinatal mortality. 1986. pp. 813–825. [Google Scholar]
  39. Waibl H. Quantitative Untersuchungen am Schweinethymus. (Quantitative studies on the thymus of the pig) Zbl. Vet. Med. C. 1982;11:234–241. doi: 10.1111/j.1439-0264.1982.tb00991.x. [DOI] [PubMed] [Google Scholar]
  40. Valdès-Dapena MH. Histology of the Fetus and Newborn. Philadelphia: W. B. Saunders Co.; 1979. p. 57. [Google Scholar]

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