Skip to main content
PMC home page
Acta Veterinaria Scandinavica logoLink to Acta Veterinaria Scandinavica
. 1987 Mar 1;28(1):1–8. doi: 10.1186/BF03548250

Autosomal Trisomy in a Heifer

Autosomal trisomi hos en kviga

Auli Mäkinen 11,21,✉, Ilkka Alitalo 11,21, Matti Alanko 11,21
PMCID: PMC8185787  PMID: 3687640

Abstract

A malformed Ayrshire heifer had one additional autosome in all the lymphocyte metaphases studied. Chromosome banding techniques showed the karyotype of the calf to be 2n = 61, XX, +24.

Slight prognathia of the lower jaw and peculiar abbrevations in the structure of the genitals were the most apparent anomalies, in addition to heart abnormalities, a poorly-closed urachus and slow growth rate.

Keywords: autosomal trisomy, congenital malformations, chromosome banding analysis.

Full Text

The Full Text of this article is available as a PDF (2.9 MB).

Acknowledgements

We are grateful to veterinarian Eero Remes for his kind cooperation in referring the calf of the present study. We would also like to thank Tarja Väisänen for her excellent laboratory assistance, Dr. Henni Höhn for her interest in this study and Drs. Ingemar Gustavsson and Dino di Berardino for their comments on the karyotype.

References

  1. Alberman E, Creasy MR. Frequency of chromosomal abnormalities in miscarriers and perinatal death. J. Med. Genet. 1977;14:313–315. doi: 10.1136/jmg.14.5.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carr DH. Genetic basis of abortation. Annu. Rev. genet. 1971;5:65–80. doi: 10.1146/annurev.ge.05.120171.000433. [DOI] [PubMed] [Google Scholar]
  3. Chandley AC. The origin of chromosomal aberrations in man and their potential for survival and reproduction an the adult human population. Ann. Génét. 1981;24:5–11. [PubMed] [Google Scholar]
  4. Di Berardino D, Lannuzzi L. Detailed description of R-banded bovine chromosomes. J. Hered. 1982;73:434–4138. doi: 10.1093/oxfordjournals.jhered.a109693. [DOI] [PubMed] [Google Scholar]
  5. Di Berardino D, Iannuzzi L, Lioi MB. The high-resolution RBA-banding pattern of bovine chromosomes. Cytogenet. Cell Genet. 1985;39:136–139. doi: 10.1159/000132122. [DOI] [PubMed] [Google Scholar]
  6. Dunn HO, Johnson RH., Jr A 61 XY cell line in a calf with extreme brachygnathia. J. Dairy Sei. 1972;55:524–526. doi: 10.3168/jds.S0022-0302(72)85526-7. [DOI] [PubMed] [Google Scholar]
  7. Dutrillaux B, Laurent C, Couturier J, Lejeune J. Coloration des chromosomes humains par 1’acridine orange après traitement par le 5 bromodeoxyuridine. (Acridine orange staining method in human chromosomes treated with 5 bromodeoxyuridine) C. R. Acad. Sc. (Paris) 1973;276:3179–3181. [PubMed] [Google Scholar]
  8. Ettala E, Ruohomäki H: Lypsykaijan pitkäaikaiskoe: Erirotuisten hiehojen kasvatulokset. (The growth rate in female calf of different breed). Maaseudun Tulevaisuus, Koetoiminta ja Käytänto 16.12.1980.
  9. Fechheimer NS. Cytogenetics in animal production. J. Dairy Sei. 1979;62:844–853. doi: 10.3168/jds.S0022-0302(79)83336-6. [DOI] [PubMed] [Google Scholar]
  10. Gluhovschi N, Bistriceanu M. Untersuchungen zur Chromosomenpathologie in der Veterinärmedizin. (Veterinary medicine and cytogenetics). 1. europäisches Kolloquium über Zytogenetik in Veterinärmedizin und Säugetierkunde. Giessen 1970, in Giessener beitr. Erbpath. Zuchthyg. Sonderheft. 1970;1:93–100. [Google Scholar]
  11. Gluhovschi N, Bistriceanu M, Palicica R. Les troubles de la reproduction chez les animeaux domestiques dus à des modifications du genome. (Cytogenetic studies of domestic animals with reproductive problems). Cah. Méd. Vét. 1975;44:155–163. [Google Scholar]
  12. Gustavsson I. Chromosome aberrations and their influence on the reproductive performance of domestic animals - a review. Z. Tierzüchtg. Züchtgsbiol. 1980;97:176–195. doi: 10.1111/j.1439-0388.1980.tb00925.x. [DOI] [Google Scholar]
  13. Gustavsson I. Banding techniques in chromosome analysis of domestic animals. Adv. Vet. Sci. Comp. Med. 1980;24:245–289. [PubMed] [Google Scholar]
  14. Gustavsson I, Settergren I, King WA. Occurrence of two different reciprocal translocations in the same litter of domestic pigs. Hereditas. 1983;99:257–267. doi: 10.1111/j.1601-5223.1983.tb00898.x. [DOI] [PubMed] [Google Scholar]
  15. Hare WCD, Singh EL, Betteridge KJ, Eaglesome MD, Randall GCB, Mitchell D, Bilton RJ, Trounson AO. Chromosomal analysis of 159 bovine embryos collected 12 to 18 days after estrus. Can. J. Genet. Cytol. 1980;22:615–626. doi: 10.1139/g80-067. [DOI] [PubMed] [Google Scholar]
  16. Herzog A. Autosomale Trisomie bei der letalen Brachygnatie des Rindes (bovines Trisomie- Brachygnathia-syndrom). (Autosomal trisomy in cattle with brachygnathia inferior) Dtsch. Tierärztl. Wschr. 1974;81:77–100. [PubMed] [Google Scholar]
  17. Herzog A, Höhn H. Autosomale Trisomie bei einem Kalb mit Brachygnathia inferior und Ascites congenitus. (Autosomal trisomy in a calf with Brachygnathia inferior and congenital edema) Dtsch. Tierärztl. Wschr. 1968;75:604–606. [PubMed] [Google Scholar]
  18. Herzog A, Höhn H. Autosomale Trisomie bei der letalen Brachygnathie des Rindes. (Autosomal trisomy in cattle with lethal brachygnathia) Cytogenetics. 1971;10:347–355. doi: 10.1159/000130153. [DOI] [PubMed] [Google Scholar]
  19. Herzog A, Höhn H, Olyschläger F, Rusch P. 17-Trisomie-Mosaik beim Rind. (17-trisomicmosaic cattle) Berl. Münch. Tierärztl. Wschr. 1982;95:352–354. [PubMed] [Google Scholar]
  20. Herzog A, Höhn H, Rieck GW. Survey of recent situation of chromosome pathology in different breeds of german cattle. Ann. Génét. Sél. Anim. 1977;9:471–491. doi: 10.1186/1297-9686-9-4-471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Höhn H, Herzog A. Zwei weitere Fälle von autosomaler trisomie bei Kälbern mit Brachygnathia inferior und anderen Missbildungen. (Two additional cases of autosomal trisomy in calves with brachygnathia inferior and other anerrations) Giessener Beitr. Erbpath. Zuchthyg. 1970;3:1–7. [Google Scholar]
  22. Jacobs PA, Morton NE. Origin of human trisomies and polyploids. Hum. Hered. 1977;27:59–72. doi: 10.1159/000152852. [DOI] [PubMed] [Google Scholar]
  23. King WA, Linares T, Gustavsson I, Bane A. Presumptive translocation type in embryos sired by bulls heterozygous for the 1/29 translocation. Hereditas. 1980;92:167–169. doi: 10.1111/j.1601-5223.1980.tb01690.x. [DOI] [PubMed] [Google Scholar]
  24. King WA, Linares T, Gustavsson I. Cytogenetics of preimplantation embryos sired by bulls heterozygous for the 1/29 translocation. Hereditas. 1981;94:219–224. doi: 10.1111/j.1601-5223.1981.tb01756.x. [DOI] [PubMed] [Google Scholar]
  25. Lejeune J, Gautier M, Turpin R. Etude des chromosomes somatiques de neuf enfants mongoliens. (Extra somatic chromosome in newborn with mongolism). C. R. Acad. Sci. 1959;245:1721–1722. [PubMed] [Google Scholar]
  26. Lin CC, Newton DR, Church RB. Identification and nomenclature for G-banded bovine chromosomes. Can. J. Genet. Cytol. 1977;79:271–282. doi: 10.1139/g77-030. [DOI] [Google Scholar]
  27. Mayr B, Krutzler H, Auer H, Scheieger W, Sasshofer K, Glawischnig E. A viable calf with trisomy 22. Cytogenet. Cell genet. 1985;39:77–79. doi: 10.1159/000132109. [DOI] [PubMed] [Google Scholar]
  28. Mori M, Sasaki M, Makino S, Ishikawa T, Kawata K. Autosomal trisomy in a malformed newborn calf. Proc. Japan Acad. 1969;45:955–957. doi: 10.2183/pjab1945.45.955. [DOI] [Google Scholar]
  29. Popescu CP. Proc. 4th Eur. Colloq. Cytogenet. Dornest. Anim. 1980. Cytogenetic study on embryos sired by a bull carrier of 1/29 translocation; pp. 182–186. [Google Scholar]
  30. Proceedings of the First International Conference for the Standardization of Banded Karyotypes of Domestic Animals. Reading, England. 1976. (Eds. Ford CE, Pollock DL & Gustavsson I). Hereditas 1980, 92, 145–162. [DOI] [PubMed]
  31. Rieck GW. Proc. 6th Eur. Colloq. Cytogenet. Dornest. Anim. 1984. Veterinary medicine and cytogenetics; pp. 20–34. [Google Scholar]
  32. Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971;2:971–972. doi: 10.1016/S0140-6736(71)90287-X. [DOI] [PubMed] [Google Scholar]
  33. Sumner AT. A simple technique for demonstrating centrometric heterochromatin. Exp. Cell. Res. 1072;75:304–306. doi: 10.1016/0014-4827(72)90558-7. [DOI] [PubMed] [Google Scholar]
  34. Tschudi P, Ueltschi G, Martiq J, Küpfer U. Autosomale Trisomie als Ursache eines hohen Ventrikel-septumdefekts bei einem Kalb der Simmentalerrasse. (Autosomal trisomy as the cause for defects of the interventricular septum in a Simmental calf) Schweiz. Arch. Tierheilkd. 1975;777:335–340. [PubMed] [Google Scholar]
  35. Tschudi P, Zahner B, Küpfer U, Stämpfli G. Chromosomenuntersuchungen an schweizerischen Rindermassen. (Chromosome investigation of Brown Swiss cattle) Schweiz. Arch. Tierheilkd. 1977;119:329–336. [PubMed] [Google Scholar]

Articles from Acta Veterinaria Scandinavica are provided here courtesy of BMC

RESOURCES