IL-6 (n = 4935)				CRP (n = 4887)
	Crude model		Covariate-adjusteda		Crude model		Covariate-adjusteda
	logIL-6	95 % CI	logIL-6	95 % CI	logCRP	95 % CI	logCRP	95 % CI
ACE score
0 ACEs	Ref		Ref		Ref		Ref
1 ACE	0.03	−0.03, 0.09	0.02	−0.04, 0.08	0.02	−0.06, 0.92	0.01	−0.07, 0.09
2 ACEs	0.01	−0.07, 0.08	−0.01	−0.09, 0.07	−0.07	−0.18, 0.03	−0.08	−0.19, 0.02
3 ACEs	0.05	−0.06, 0.17	0.04	−0.08, 0.15	−0.003	−0.15, 0.15	−0.01	−0.16, 0.14
4+ ACEs	0.08	−0.003, 0.16	0.04	−0.05, 0.13	−0.07	−0.18, 0.04	−0.09	−0.21, 0.03
Individual ACEs
Parental separation/divorce	0.16	0.08, 0.24	0.13	0.05, 0.21	0.02	−0.08, 0.12	0.02	−0.08, 0.13
Parental alcohol problems	−0.15	−0.29, -0.003	−0.15	−0.29, -0.003	−0.07	−0.25, 0.12	−0.06	−0.25, 0.13
Maternal mental health problems	0.07	0.02, 0.12	0.05	−0.004, 0.11	−0.005	−0.07, 0.06	−0.01	−0.09, 0.07
Paternal mental health problems	−0.05	−0.12, 0.02	−0.08	−0.15, -0.004	−0.07	−0.16, 0.03	−0.07	−0.17, 0.03
Parental convictions	−0.23	−0.41, -0.04	−0.22	−0.41, -0.04	−0.09	−0.33, 0.15	−0.08	−0.33, 0.16
Inter-parental violence	0.09	−0.02, 0.21	0.07	−0.05, 0.18	0.005	−0.15, 0.16	0.01	−0.15, 0.16
Physical abuse	−0.01	a−0.08, 0.07	−0.01	−0.08, 0.07	−0.01	−0.11, 0.09	0.004	−0.10, 0.11
Emotional abuse	−0.09	−0.17, -0.01	−0.10	−0.18, -0.02	−0.11	−0.21, -0.002	−0.11	−0.21, 0.004
Parental drug use	−0.04	−0.20, 0.12	−0.04	−0.20, 0.12	−0.20	−0.41, 0.02	−0.19	−0.41, 0.03
Sexual abuse	0.15	−0.30, 0.61	0.13	−0.33, 0.58	0.21	−0.39, 0.80	0.21	−0.39, 0.80
LCA-derived ACE clusters
Low ACEs (81.1 %)	Ref		Ref		Ref		Ref
Maternal mental health problems (10.3 %)	0.04	−0.04, 0.12	0.01	−0.07, 0.09	−0.09	−0.19, 0.02	−0.09	−0.20, 0.02
Maternal mental problems + physical abuse (6.3 %)	−0.06	−0.16, 0.04	−0.07	−0.17, 0.03	−0.05	−0.18, 0.08	−0.05	−0.18, 0.09
Parental conflict, mental health problems & emotional abuse (2.4 %)	0.14	−0.02, 0.30	0.08	−0.09, 0.24	0.05	−0.16, 0.26	0.04	−0.18, 0.26