Errors occurred in the article by Rosen et al, “Utility of Symptoms to Predict Treatment Outcomes in Obstructive Sleep Apnea Syndrome” published in the March 2015 issue of Pediatrics (2015;135[3]:e662–671; doi:10.1542/peds.2014-3099).
On page e666, in Table 2, for the NEPSY-A/E score row, the column data for Baseline, Follow-up, Change From Baseline, and Effect Size were incorrect. The correct data are shown in the accompanying table.
TABLE 2.
Summary of Behavioral, Sleepiness, and Quality of Life Measures at Baseline and at 7-Month Follow-up After Adenotonsillectomy
| Neurobehavioral Measure | No. With Available Data (Baseline/Follow-up) | Baseline | Follow-up | Change From Baselinea | Pb | Effect Size |
|---|---|---|---|---|---|---|
| NEPSY-A/E score | (184/183) | 102.3 ± 15.7 | 109.2 ± 15.4 | 7.1 ± 13.7, n = 183 | <.001 | –0.44 |
| BRIEF score | (185/184) | 49.5 ± 10.8 | 46.2 ± 11.3 | −3.3 ± 8.3, n = 184 | <.001 | 0.30 |
| Conners’ Rating Scale | (185/182) | 52.1 ± 11.4 | 49.2 ± 10.8 | −2.9 ± 9.9, n = 182 | <.001 | 0.26 |
| CBCL score | (180/181) | 52.1 ± 10.9 | 48.2 ± 12.0 | −3.9 ± 8.0, n = 178 | <.001 | 0.34 |
| PedsQL (Child) | (184/184) | 68.8 ± 15.4 | 72.3 ± 15.2 | 3.6 ± 17.2, n = 183 | .006 | −0.23 |
| PedsQL (Parent) | (185/184) | 78.8 ± 15.4 | 84.5 ± 14.9 | 5.7 ± 14.6, n = 184 | <.001 | −0.37 |
| OSAS-18 score | (184/183) | 52.8 ± 17.7 | 30.7 ± 13.8 | −21.9 ± 15.9, n = 182 | <.001 | 1.39 |
| ESS | (185/185) | 7.1 ± 4.7 | 5.0 ± 4.4 | −2.0 ± 4.3, n = 185 | <.001 | 0.44 |
Data are summarized as mean ± SD.
Number of participants with available change data (baseline minus follow-up) differs slightly from the number with available data at follow-up: CBCL (n = 178), PedsQL Child (n = 183), OSAS-18 (n = 182).
P values were based on paired t test of baseline and follow-up.
On page e668, in Table 5, the Spearman correlation coefficient data in the NEPSY A/E column were incorrect. The correct data are shown in the accompanying table.
TABLE 5.
Spearman Correlations (ρ) Between Baseline PSQ or PSG and Outcomes (7-Month Change Scores) After Adenotonsillectomy
| NEPSY-AE | BRIEF | Conners | CBCL | PedsQL Child | PedsQL Parent | OSAS-18 | ESS | |
|---|---|---|---|---|---|---|---|---|
| OSAS Assessments | ||||||||
| PSQ scale | ||||||||
| Total score | –0.064 | 0.329*** | 0.446*** | 0.386*** | –0.181** | –0.379*** | 0.338*** | 0.185** |
| Snoring subscale | 0.033 | –0.036 | 0.047 | 0.056 | 0.025 | 0.038 | 0.015 | 0.056 |
| Sleepiness subscale | –0.085 | 0.037 | 0.094 | 0.079 | –0.062 | –0.125 | 0.215** | 0.077 |
| Inattention and hyperactivity subscale | –0.085 | 0.495*** | 0.573*** | 0.471*** | –0.232** | –0.384*** | 0.279*** | 0.117 |
| PSG variables | ||||||||
| AHI | 0.026 | –0.023 | –0.014 | –0.002 | –0.165* | –0.036 | 0.048 | 0.115 |
| ODI3% | –0.002 | 0.011 | 0.034 | 0.021 | –0.121 | –0.071 | 0.088 | 0.124 |
| ETCO2 values >50 mm Hg | 0.102 | –0.054 | –0.072 | –0.050 | –0.067 | 0.080 | –0.149 | 0.102 |
| Arousal index | 0.055 | –0.083 | –0.084 | –0.122 | –0.068 | 0.121 | 0.055 | –0.093 |
| Total sleep time (min) | 0.088 | –0.118 | –0.132 | –0.092 | 0.008 | 0.028 | –0.150* | 0.095 |
| Percentage N1 sleep | –0.046 | 0.032 | 0.046 | –0.024 | –0.093 | 0.062 | 0.032 | –0.038 |
| Percentage N2 sleep | –0.069 | –0.129 | –0.064 | –0.135 | 0.135 | 0.029 | –0.025 | 0.131 |
| Percentage N3 sleep | 0.154* | 0.107 | 0.068 | 0.144 | –0.028 | –0.094 | 0.016 | –0.155* |
| Percentage REM sleep | 0.023 | 0.123 | 0.094 | 0.089 | –0.050 | –0.015 | –0.057 | 0.165* |
N1, non-REM stage 1 sleep; N2, non-REM stage 2 sleep; N3, non-REM stage 3 sleep.
*P value < 0.05; **P ≤ .01; ***P ≤ .001
On page e669, in Table 7, the logistic regression data in the Higher NEPSY-AE row for PSG and AHI were incorrect. The correct data are shown in the accompanying table.
TABLE 7.
Logistic Regression of Outcome Improvement† Across 7 Months on Baseline PSQ Scale and AHI
| No. (%) of Participants With Improvement From Baselinea | OR (95% CI) | P | |
|---|---|---|---|
| Higher NEPSY-AE | 91 (50%) | ||
| PSQ | 1.02 (0.75–1.38) | .91 | |
| AHI | 1.08 (0.89–1.47) | .61 | |
| Lower BRIEF | 64 (35%) | ||
| PSQ | 1.45 (1.04–2.02) | .03 | |
| AHI | 1.14 (0.82–1.57) | .44 | |
| Lower Connors | 54 (30%) | ||
| PSQ | 1.57 (1.11–2.23) | .01 | |
| AHI | 1.01 (0.71–1.42) | .97 | |
| Lower CBCL | 79 (44%) | ||
| PSQ | 1.58 (1.13–2.21) | .008 | |
| AHI | 1.01 (0.73–1.40) | .95 | |
| Higher PedsQL (child) | 73 (40%) | ||
| PSQ | 1.27 (0.82–1.97) | .29 | |
| AHI | 0.66 (0.39–1.11) | .11 | |
| Higher PedsQL (parent) | 66 (36%) | ||
| PSQ | 1.69 (1.09–2.60) | .02 | |
| AHI | 0.89 (0.57–1.41) | .63 | |
| Lower OSAS-18 | 147 (81%) | ||
| PSQ | 2.16 (1.38–3.38) | .0008 | |
| AHI | 1.10 (0.72–1.67) | .67 | |
| Lower ESS | 82 (44%) | ||
| PSQ | 1.72 (1.24–2.38) | .001 | |
| AHI | 1.05 (0.77–1.43) | .77 |
Logistic regression adjusted for age, gender, race, BMI z score. PSG and AHI normalized to reflect the effect of a 1 SD increase (equivalent to 0.18 points on the PSQ or 5.8 points in the AHI), after adjustment for the baseline value of the other predictor and other covariates in the model.
Clinically meaningful improvement defined as an improvement in the morbidity measure by ≥0.5 SD from its baseline mean.