Figure 7. Summary of developmental timelines of Purkinje cell activity and morphology.

Left, selected features for physiological activity, represented by simple spike firing rate in vitro, simple spike rate in vivo and complex spike rate in vivo. Below the graphs periods of rapid development are indicated, either based on our data or by extrapolation when first recorded levels are already high, see e.g. simple spike rate in vivo. Right, selected morphological features, represented by dendritic shape, axonal shape (both as total number of intersections) and climbing fibers (as % of climbing occupation of molecular layer). Note that, although not all data points are available and extrapolation is required, the general trend emerging is that of rapid development in the second postnatal week (P7 to P14) and that Lobule III/ZebrinII– PCs typical complete rapid development later. Z– = ZebrinII negative, Z+ = ZebrinII positive, SS = simple spike, CS = complex spike.