Abstract
Objective
The aim of this study is to analyze the effect of the artificial tear drop administration time on the regularity of the corneal surface in patients with dry eye.
Methods
Patients with cataract who were admitted to the hospital from January 2018 to December 2018 were divided into four groups (A, B, C, and D) based on their grade of noninvasive tear break-up time (NIBUT) and the concentration of the eye drops used. Groups A and C were classified as NIBUT grade 1 (NIBUTf of 6–9 s and NIBUTav of 8–13 s), and groups B and D were classified as NIBUT grade 2 (NIBUTf of <5 s and NIBUTav of ≤7 s). Groups A and B received 0.1% sodium hyaluronate eye drops, and groups C and D received 0.3% sodium hyaluronate eye drops.
Results
In group A, there was a significant increase (p < 0.05) in the surface regularity index (SRI) and the surface asymmetry index (SAI) measured 1 s after eye drop administration. In group B, there was a significant decrease (p < 0.05) in the SRI and the SAI measured 1 s and 5 and 10 min after eye drop administration. In group C, there was a significant increase (p < 0.05) in the astigmatism degree, SRI, SAI, and irregular astigmatism index (IAI) measured 1 s after eye drop administration. There was a significant decrease (p < 0.05) in potential visual acuity (PVA). In group D, there was a significant increase in the IAI and Q value (parameters of aspheric characteristics of cornea, corneal Q value) measured 1 s after eye drop administration as well as a significant decrease in PVA (p < 0.05).
Conclusion
The use of 0.1% sodium hyaluronate eye drops in patients with dry eye aid the temporary recovery of corneal surface regularity and the stability of tear film. The 0.1% sodium hyaluronate had a significant effect for the first 10 min after treatment.
Keywords: dry eye, corneal topography, corneal surface regularity, tear film, sodium hyaluronate
Introduction
Dry eye is the most common clinically observed ocular surface disease. Symptoms of dry eye include burning, itching, foreign body sensation, and blurred and fluctuating vision. These symptoms may damage the ocular surface and negatively affect the patient’s quality of life.1–3 Previous studies suggest that visual disorders in patients with dry eye are primarily the result of an increase in corneal surface irregularities and reduction in tear film stability. The tear film not only nourishes and protects the ocular surface, but also forms a smooth optical interface beneficial to clear retinal imaging on the corneal surface.4–7 With the development of cataract surgery and intraocular lens technology, a greater potential for the recovery of visual quality after cataract surgery has appeared. The regularity of the corneal surface is an important metric for determining a patient’s intraocular lens power prior to cataract surgery. It is important to stabilize the tear film and enhance corneal regularity before surgery.
Dry eye is one of the most common clinically observed ocular surface diseases. An epidemiological survey carried out in Salisbury, Maryland found that as many as 15% of individuals aged over 65 years experienced dry eye.8 The traditional ways of diagnosing and evaluating dry eye, such as the tear secretion test and tear film break-up time measurement, produce variable results and lead to discomfort in the examinee’s ocular surface.9,10 In recent years, ophthalmic examination methods, including corneal topography and ocular surface analysis, have become widely used. These methods provide new ways of diagnosing and evaluating dry eye.11 However, there has not yet been an in-depth study of the impact of artificial tears on changes in optical properties in patients with dry eye. In the present study, a noninvasive ocular surface analyzer (OCULUS Keratograph; OCULUS, Wetzlar, Germany) and a corneal topographer (OPD-Scan III; NIDEK Co., Ltd., Tokyo, Japan) were used to analyze and evaluate the effect of the concentration and administration time of sodium hyaluronate eye drops on corneal surface regularity in patients with dry eye.
Materials and Methods
General Data
Dry eye classification was performed on 104 patients with cataract who were admitted to the hospital from January 2018 to December 2018. The members of the entire patient group were aged 50–81 y, with an average age of 65.05 ± 7.59 y. The patients (124 eyes) were divided on the basis of noninvasive tear break-up time (NIBUT), as measured prior to surgery by the OCULUS Keratograph noninvasive ocular surface analyzer. Next, they were randomly selected to receive either 0.1% or 0.3% sodium hyaluronate eye drops. Group A comprised 31 cases (33 eyes), with an average age of 66.79 ± 7.46 y. Group B comprised 20 cases (30 eyes), with an average age of 64.57 ± 8.34 y. Group C comprised 28 cases (31 eyes), with an average age of 64.33 ± 6.59 y. Group D comprised 25 cases (30 eyes), with an average age of 65.05 ± 7.58 y.
None of the patients in the four groups exhibited signs of a condition that could increase tear secretion, namely chronic dacryocystitis and abnormalities in the ocular surface structure. The patients had no history of eye surgery or trauma and had never worn corneal contact lenses or used artificial tears or other drugs affecting ocular surface function in the previous six months. Patients with corneal irregularities of ≥2.0 mm (relatively high irregular astigmatism) were excluded from the study.
The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the ethics committee of the Fourth Affiliated Hospital of China Medical University, and informed consent was taken from each patient.
Apparatus and Methods
(1) Inspection via noninvasive ocular surface analysis: the OCULUS Keratograph noninvasive ocular surface analyzer (OCULUS, Wetzlar, Germany) was used to inspect the patients’ eyes. In every patient, each eye was inspected twice by the same technician, and the higher-quality images were selected for analysis. The two inspections were separated by an interval of 30 min so that the data would not be affected by patient fatigue. The NIBUT was recorded and graded for each patient. The grading criteria were as follows: (i) no dry eye (grade 0) – first NIBUT (NIBUTf) of ≥10 s and average NIBUT (NIBUTav) of ≥14 s; (ii) suspected dry eye (grade 1) – NIBUTf of 6–9 s and NIBUTav of 8–13 s; (iii) dry eye (grade 2) – NIBUTf of <5 s and NIBUTav of ≤7 s. The humidity and temperature of the inspection room were kept constant. (2) Examination via corneal topography: the NIDEK OPD-Scan III corneal topographer (NIDEK, Tokyo, Japan) was used to examine the patients’ eyes. In every patient, each eye was inspected by the same technician. The technician recorded the average corneal curvature, degree of astigmatism, Q value (degree of corneal asphericity), surface regularity index (SRI), surface asymmetry index (SAI), irregular astigmatism index (IAI), and potential visual acuity (PVA). The OPD-Scan III recorded each measurement in every patient prior to eye drop administration and 1 s and 5, 10, 15, 20, 30, 60, and 120 min after eye drop administration. (3) Group A (31 cases, 33 eyes): the patients were classified as NIBUT grade 1 with symptoms of dry eye and treated with 0.1% sodium hyaluronate eye drops. Group B (20 cases, 30 eyes): the patients were classified as NIBUT grade 2 with symptoms of dry eye and treated with 0.1% sodium hyaluronate eye drops. Group C (28 cases, 31 eyes): the patients were classified as NIBUT grade 1 with symptoms of dry eye and treated with 0.3% sodium hyaluronate eye drops. Group D (25 cases, 30 eyes): the patients were classified as NIBUT grade 2 with symptoms of dry eye and treated with 0.3% sodium hyaluronate eye drops. (4) The patients in the present study all volunteered to participate and gave their written informed consent. The patients did not use any drugs before the study. During the interval between the two inspections, the patients closed their eyes and rested in order to avoid inaccurate data due to fatigue.
Statistical Analysis
The SPSS 17.0 software (IBM Corp., Armonk, NY, USA) was used to analyze the data. A one-way analysis of variance was used each time to compare the indices. If the homogeneity of variance was satisfied, a significant difference t-test was performed. Otherwise, Dunnett’s t-test was used. A p value of <0.05 was considered statistically significant.
Results
Comparison of the Characteristics in Patients Before Treatment with Sodium Hyaluronate Eye Drops
There was no statistical difference in the average age of the patients between the four groups (p > 0.05). There was also no significant difference between groups A and C or groups B and D in the examination results prior to treatment with sodium hyaluronate eye drops (p > 0.05).
Comparison of the Indices for Group a Before and After Treatment with 0.1% Sodium Hyaluronate Eye Drops
There was no statistically significant difference in the average corneal curvatures, degrees of astigmatism, Q values, or IAIs measured before and after treatment. The SRI increased 1 s after treatment and was significantly different from the values recorded before treatment and the values recorded 5, 10, 15, 20, 30, 60, and 120 min after treatment (p < 0.05, Table 1). The SAI increased 1 s and 5 min after treatment and was significantly different from the values recorded before treatment and the values recorded 10, 15, 20, 30, 60, and 120 min after treatment (p < 0.05, Table 1). These results show that the corneal surface regularity of patients with suspected dry eye (NIBUT grade 1) decreased after treatment with 0.1% sodium hyaluronate eye drops and then returned to the pre-treatment level. It is possible that this initial decrease took place due to part of the tear film thickening after the application of the sticky eye drops to the original, relatively stable tear film, resulting in uneven tear film distribution and affecting cornea regularity.
Table 1.
Comparison of the Indices for Group A Before and After Treatment with 0.1% Sodium Hyaluronate Eye Drops (X±s)
| Time | Corneal Curvature | Astigmatism | Q Value | SRI | SAI | IAI | PVA |
|---|---|---|---|---|---|---|---|
| Before treatment | 44.29±1.46 | −1.07±0.76 | −0.18±0.18 | 0.56±0.24 | 0.47±0.15 | 0.48±0.04 | 1.15±0.15 |
| 1 sec after treatment | 43.95±1.56 | −1.32±0.94 | −0.03±0.37 | 0.77±0.25 | 0.59±0.16** | 0.51±0.05* | 0.97±0.13 |
| 5 min after treatment | 44.28±1.51 | −1.02±0.83 | −0.14±0.33 | 0.59±0.27 | 0.57±0.47 | 0.48±0.05* | 1.14±0.19 |
| 10 min after treatment | 44.28±1.50 | −1.03±0.81 | −0.17±0.41 | 0.52±0.25 | 0.43±0.17 | 0.47±0.05 | 1.18±0.16 |
| 15 min after treatment | 44.30±1.48 | −1.01±0.81 | −0.17±0.22 | 0.51±0.25 | 0.45±0.16 | 0.47±0.05 | 1.17±0.19 |
| 20 min after treatment | 44.27±1.51 | −1.05±0.80 | −0.14±0.26 | 0.52±0.28 | 0.46±0.19 | 0.47±0.05 | 1.14±0.16 |
| 30 min after treatment | 44.29±1.48 | −1.03±0.76 | −0.24±0.44 | 0.53±0.33 | 0.47±0.18 | 0.47±0.05 | 1.16±0.17 |
| 60 min after treatment | 44.28±1.53 | −1.13±0.87 | −0.17±0.24 | 0.53±0.27 | 0.46±0.21 | 0.47±0.04 | 1.15±0.17 |
| 120 min after treatment | 44.28±1.48 | −1.00±0.81 | −0.22±0.38 | 0.53±0.25 | 0.45±0.16 | 0.47±0.05 | 1.15±0.16 |
Notes: For all preparations. * and **Indicate significant correlation and correlation at P < 0.05 level of repeated measurement ANOVA, respectively. P < 0.01 level was significantly correlated with the following table.
Comparison of the Indices for Group B Before and After Treatment with 0.1% Sodium Hyaluronate Eye Drops
There was no statistically significant difference in the average corneal curvatures, degrees of astigmatism, Q values, or IAIs measured before and after treatment. The SRI and SAI both decreased 1 s and 5 and 10 min after treatment, and they were significantly different from the values recorded before treatment and the values recorded 15, 20, 30, 60, and 120 min after treatment (p < 0.05, Table 2). These results show that the corneal surface regularity of patients with dry eye (NIBUT grade 2) initially improved after treatment with 0.1% sodium hyaluronate eye drops but decreased again 15 min after treatment. This pattern of change suggests that the 0.1% sodium hyaluronate eye drops have a degree of viscosity that initially aided the regular recovery of the cornea. However, this effect gradually weakened with time.
Table 2.
Comparison of the Indices for Group B Before and After Treatment with 0.1% Sodium Hyaluronate Eye Drops (X±s)
| Time | Corneal Curvature | Astigmatism | Q Value | SRI | SAI | IAI | PVA |
|---|---|---|---|---|---|---|---|
| Before treatment | 44.56±1.44 | −0.97±0.88 | −0.57±0.75 | 0.63±0.14 | 0.58±0.11 | 0.47±0.04 | 1.13±0.10 |
| 1 sec after treatment | 44.38±1.16 | −0.96±0.83 | 0.05±0.88 | 0.51±0.17* | 0.45±0.094* | 0.46±0.037 | 1.15±0.12 |
| 5 min after treatment | 44.61±1.35 | −0.84±0.83 | −0.61±0.96 | 0.52±0.17* | 0.49±0.09* | 0.45±0.062 | 1.15±0.12 |
| 10 min after treatment | 44.59±1.54 | −0.72±0.78 | −0.62±1.13 | 0.47±0.12* | 0.45±0.11* | 0.45±0.05 | 1.15±0.09 |
| 15 min after treatment | 44.59±1.48 | −0.88±0.74 | −0.12±0.45 | 0.59±0.15 | 0.54±0.15 | 0.46±0.04 | 1.15±0.09 |
| 20 min after treatment | 44.59±1.54 | −1.00±0.72 | −0.34±0.54 | 0.64±0.116 | 0.51±0.13 | 0.46±0.039 | 1.13±0.10 |
| 30 min after treatment | 44.53±1.54 | −0.94±0.88 | −0.33±0.46 | 0.60±0.14 | 0.57±0.11 | 0.46±0.044 | 1.13±0.10 |
| 60 min after treatment | 44.72±1.48 | −0.72±1.06 | −0.56±1.22 | 0.56±0.19 | 0.50±0.124 | 0.45±0.04 | 1.13±0.10 |
| 120 min after treatment | 44.56±1.49 | −0.78±1.21 | −0.07±0.09 | 0.65±0.266 | 0.54±0.14 | 0.46±0.05 | 1.10±0.15 |
Notes: For all preparations. *Indicate significant correlation at P < 0.05 level of repeated measurement ANOVA, P < 0.01 level was significantly correlated with the following table.
Comparison of the Indices for Group C Before and After Treatment with 0.3% Sodium Hyaluronate Eye Drops
There was no statistically significant difference in the average corneal curvatures or Q values measured before and after treatment. The degree of astigmatism and the IAI increased 1 s after treatment, while the PVA decreased 1 s after treatment. Each of these values was significantly different to the values recorded before treatment and the values recorded 5, 10, 15, 20, 30, 60, and 120 min after treatment (p < 0.05, Table 3). The degree of astigmatism returned to its pre-treatment level 5 min after treatment, and the IAI and the PVA returned to their pre-treatment levels 10 min after treatment. The SRI and the SAI increased by a statistically significant degree 1 s after treatment (p < 0.05, Table 3). However, both returned to their pre-treatment levels 10 min after treatment. These results show that the corneal surface regularity of patients with suspected dry eye (NIBUT grade 1) temporarily decreased after treatment with 0.3% sodium hyaluronate eye drops. This temporary decrease may be the result of the highly viscous eye drops not only being strongly retained on the surface of the eye, but also increasing the amount of tear fluid. After the eye drops were applied to the original, relatively stable tear film, part of the tear film thickened noticeably, resulting in uneven tear film distribution and affected cornea regularity.
Table 3.
Comparison of the Indices for Group C Before and After Treatment with 0.3% Sodium Hyaluronate Eye Drops (X±s)
| Time | Corneal Curvature | Astigmatism | Q Value | SRI | SAI | IAI | PVA |
|---|---|---|---|---|---|---|---|
| Before treatment | 44.06±1.04 | −0.88±0.49 | −0.28±0.26 | 0.53±0.22 | 0.41±0.08 | 0.47±0.04 | 1.17±0.11 |
| 1 sec after treatment | 43.92±1.24 | −1.36±0.80* | −0.15±0.84 | 0.89±0.29* | 0.67±0.25* | 0.5±0.06* | 0.98±0.19** |
| 5 min after treatment | 44.08±1.07 | −1.11±0.81 | −0.13±0.43 | 0.77±0.29 | 0.52±0.21 | 0.49±0.04 | 1.06±0.15 |
| 10 min after treatment | 44.06±1.12 | −0.93±0.77 | −0.24±0.33 | 0.66±0.26 | 0.49±0.17 | 0.48±0.03 | 1.11±0.12 |
| 15 min after treatment | 44.14±1.10 | −0.92±0.50 | −0.29±0.38 | 0.67±0.25 | 0.46±0.15 | 0.48±0.04 | 1.11±0.14 |
| 20 min after treatment | 44.00±1.05 | −0.89±0.62 | −0.25±0.29 | 0.62±0.22 | 0.42±0.09 | 0.47±0.03 | 1.14±0.15 |
| 30 min after treatment | 44.07±1.09 | −0.93±0.58 | −0.20±0.229 | 0.58±0.28 | 0.45±0.14 | 0.47±0.04 | 1.16±0.17 |
| 60 min after treatment | 44.09±1.10 | −0.94±0.56 | −0.24±0.24 | 0.57±0.19 | 0.43±0.08 | 0.46±0.03 | 1.17±0.13 |
| 120 min after treatment | 44.05±1.10 | −1.02±0.68 | −0.23±0.23 | 0.62±0.25 | 0.45±0.14 | 0.47±0.04 | 1.13±0.16 |
Notes: For all preparations. * and **Indicate significant correlation and correlation at P < 0.05 level of repeated measurement ANOVA, respectively. P < 0.01 level was significantly correlated with the following table.
Comparison of the Indices for Group D Before and After Treatment with 0.3% Sodium Hyaluronate Eye Drops
The IAI increased 1 s after treatment, while the PVA decreased 1 s after treatment. Both of these values were significantly different from the values recorded before and after treatment (p < 0.05, Table 4). The Q value increased 1 s after treatment. This value was significantly different from the values recorded before treatment and the values recorded 5, 10, 15, 20, 30, 60, and 120 min after treatment (p < 0.05, Table 4). There was no statistically significant difference in the SRI or SAI, as measured before and after treatment. This suggests that the viscosity and other physical and chemical properties of the high-concentration sodium hyaluronate had a greater impact than its surface activity and surface tension. This finding is consistent with the results of Watanabe et al.12
Table 4.
Comparison of the Indices for Group D Before and After Treatment with 0.3% Sodium Hyaluronate Eye Drops (X±s)
| Time | Corneal Curvature | Astigmatism | Q Value | SRI | SAI | IAI | PVA |
|---|---|---|---|---|---|---|---|
| Before treatment | 45.08±1.54 | −1.04±0.75 | −0.40±0.33 | 0.63±0.29 | 0.48±0.13 | 0.49±0.05 | 1.10±0.10 |
| 1 sec after treatment | 45.25±2.08 | −1.33±1.62 | 0.29±0.93* | 0.84±0.29 | 0.69±0.41 | 0.55±0.071* | 0.93±0.26* |
| 5 min after treatment | 44.98±1.47 | −1.04±0.78 | −0.28±0.23 | 0.79±0.30 | 0.51±0.17 | 0.51±0.06 | 1.05±0.12 |
| 10 min after treatment | 45.04±1.50 | −0.79±0.38 | −0.23±0.21 | 0.70±0.23 | 0.46±0.14 | 0.49±0.03 | 1.07±0.10 |
| 15 min after treatment | 45.13±1.48 | −0.92±0.51 | −0.32±0.20 | 0.75±0.32 | 0.51±0.15 | 0.52±0.05 | 1.05±0.13 |
| 20 min after treatment | 45.10±1.55 | −0.85±0.51 | −0.46±0.52 | 0.70±0.32 | 0.50±0.18 | 0.49±0.05 | 1.07±0.16 |
| 30 min after treatment | 44.81±1.40 | −1.42±1.25 | −0.46±0.65 | 0.69±0.38 | 0.60±0.34 | 0.50±0.065 | 1.02±0.20 |
| 60 min after treatment | 45.15±1.50 | −0.89±0.48 | −0.34±0.28 | 0.83±0.42 | 0.55±0.28 | 0.50±0.06 | 1.03±0.14 |
| 120 min after treatment | 45.13±1.38 | −1.33±1.29 | −0.16±0.27 | 0.82±0.42 | 0.71±0.50 | 0.51±0.05 | 0.95±0.24 |
Notes: For all preparations. *Indicate significant correlation at P < 0.05 level of repeated measurement ANOVA, P < 0.01 level was significantly correlated with the following table.
Comparison of Indices Changes in the Four Groups’ (A, B, C, and D, Figure 1)
Figure 1.
Changes of the indices before and after treatment in groups A, B, C, and D. Horizontal axis: before treatment, 1 sec, 5 min, 10 min, 15 min, 20 min, 30 min, 60 min, and 120 min after treatment. Longitudinal axis: average corneal curvature (A), degree of corneal astigmatism (B), Q value (C), SRI value (D), SAI value (E), IAI value (F), and PVA (G).
There was no significant change in the average corneal curvature of any of the four groups, as measured before and after treatment with sodium hyaluronate eye drops (Figure 1A). The degree of corneal astigmatism increased to varying degrees in each group 1 s after treatment. The degree of astigmatism then decreased gradually in each group, with the largest decreases occurring between 1 s and 5 min after treatment (Figure 1B). In group D, the Q value increased significantly 1 s after treatment, reaching positive values before gradually returning to its original level 5 min after treatment (Figure 1C). In groups A, C, and D, the SRI increased 1 s after treatment; in groups A and C, the SRI reached its maximum value 1 s after treatment and then decreased to pre-treatment levels 10 min after treatment. In group B, the SRI decreased between 1 s and 10 min after treatment and increased correspondingly 15 min after treatment (Figure 1D). In groups A, C, and D, the SAI increased 1 s after treatment. In groups A and C, the SAI reached its maximum value 1 s after treatment and then decreased to its pre-treatment level 10 min after treatment. In group B, the SAI decreased between 1 s and 10 min after treatment and increased correspondingly 15 min after treatment (Figure 1E). In groups A, C, and D, the IAI increased 1 s after treatment. However, there was no obvious change in the IAI of group B, as measured before and after treatment (Figure 1F). In groups A, C, and D, the PVA decreased 1 s after treatment and returned to pre-treatment levels 10 min after treatment. In contrast, there was no obvious change in the PVA of group B, as measured before and after treatment (Figure 1G).
Discussion
When a patient has an unstable tear film or is suffering from dry eye, the symptoms of eye-burn and foreign body sensation can be accompanied by blurred and fluctuating vision. These changes in vision may be related to unstable tear film, irregular corneal surfaces, higher SRI or SAI, and lower PVA, all of which characterize patients with dry eye.13 On the basis of clinical practice, Sheppard14 suggests that attention should be paid to the presence of dry eye before proceeding with cataract surgery since this condition may affect the healing of the wound, result in changes in refractive power, and lead to the inaccurate measurement of corneal astigmatism. In doing so, dry eye may prevent cataract surgery from achieving its expected effect. In addition, the accuracy of many of the instruments commonly used prior to cataract surgery also depends on tear film stability and corneal surface regularity. As a result, it is very important that the tear film is stabilized and the corneal surface regularity restored before cataract surgery takes place.
Corneal topography provides a visual representation of the corneal surface, and software can be used to determine its parameters, including the corneal curvature, degree of corneal astigmatism, Q value, SRI, SAI, IAI, and PVA. Of these parameters, higher SRI and SAI indicate greater corneal surface irregularity11 and lower PVA. Previous studies have suggested that the SRI, SAI, IAI, PVA, Q value, and degree of corneal astigmatism are closely correlated with a reduction in vision quality in patients with dry eye.14–16 Thus, these parameters may be used as reference indices for the diagnosis of dry eye, which will aid in the evaluation of patients with dry eye prior to cataract surgery, refraction surgery, and other operations, while also making it possible to judge the effects of artificial tears on tear film reconstruction more accurate.17
Sodium hyaluronate is a type of aminodextran with a viscoelastic rheology. Its relatively high viscosity can enhance tear film stability, improve liquid retention on the surface of the cornea, and increase corneal humidity. In addition, sodium hyaluronate can promote the migration and reparation of the corneal epithelial cells. As a result, sodium hyaluronate has become an important treatment for dry eye.18–20 Previous studies have reported that 0.1% sodium hyaluronate eye drops can significantly increase the height of the lacrimal river in 3 min and that 0.3% sodium hyaluronate eye drops, where the effect is concentration dependent, can do so in 5 min.12 This indicates that sodium hyaluronate eye drops can increase the amount of tear fluid for a long period of time, where higher concentrations lead to better retention by the eye’s surface. However, no previous study has evaluated corneal surface regularity or conducted a time-effect analysis of the visual function of patients with dry eye after treatment with sodium hyaluronate. The results of the present study suggest that 0.1% sodium hyaluronate may aid in the temporary recovery of corneal surface regularity and tear film stability in patients with dry eye. Because a highly significant effect was observed within 10 min of treatment, the use of 0.1% sodium hyaluronate may improve the accuracy of corneal biometry. Once 10 min elapsed in this study, the effect was not as obvious as before due to the decreasing levels of viscosity and elasticity. However, corneal regularity and corneal biometry accuracy may decrease in patients with a relatively stable tear film. In these patients, the tear film may become thickened and unevenly distributed after the application of the viscous eye drops. Because 0.3% sodium hyaluronate has an even higher viscosity than 0.1% sodium hyaluronate, it can cause a greater degree of thickening and uneven distribution of the tear film. Thus, for patients with dry eye, it is recommended to use low concentration sodium hyaluronate to increase the accuracy of measurement as much as possible. In the present study, no drugs were used that could interfere with the experimental results, and patients closed their eyes to rest during the interval between examinations to avoid the generation of inaccurate data.
Conclusion
As a result of the present study’s relatively small sample size, the testing method had a lower degree of sensitivity and specificity, and further studies are needed in order to confirm the results. However, the present study still presents a quantitative evaluation of the effect of different concentrations of sodium hyaluronate on the temporary restoration of corneal surface regularity at different effective times and provides an objective basis for improving the accuracy of corneal biometry.
Acknowledgments
We are particularly grateful to all the people who have given us help on our article.
Funding Statement
This study was funded by National Natural Science Foundation of China science Foundation for Youth (No. 81100700). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Disclosure
The authors declare that they have no competing interests.
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