Skip to main content
. 2021 May 26;26(11):3178. doi: 10.3390/molecules26113178

Figure 3.

Figure 3

The core genomewide genetic and epigenetic networks (GWGEN). (a–c). (a) The core GWGEN of young-adult skin. The purple lines denote protein–protein interactions (PPIs). The green lines indicate transcriptional regulations by TFs and lncRNAs. The black lines represent post-transcriptional regulations by miNRAs. The total number of receptors, proteins, lncRNAs, TFs and miRNAs are 556, 3166, 136, 134 and 8, respectively. (b) The core GWGEN of middle-aged skin. The PPIs are in purple. The regulations from TFs and lncRNAs are in green. The black lines stand for the post-transcriptional regulations by miRNAs. The total number of receptors, proteins, lncRNAs, TFs and miRNAs are 499, 3190, 105, 117 and 10, respectively. (c) The core GWGEN of elderly-stage skin. The PPIs are shown in purple lines; regulations by TFs and lncRNAs are denoted in green; regulations from miRNAs are in black. The total number of receptors, proteins, lncRNAs, TFs and miRNAs are 546, 3220, 126, 102 and 6, respectively.