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. 2015 Oct 20;30(5):326–343. doi: 10.1007/s12250-015-3624-1

Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past

Rashedul Islam 1, Mohammed Salahuddin 1, Md Salahuddin Ayubi 1, Tahmina Hossain 1, Apurba Majumder 2, Andrew W Taylor-Robinson 3, Abdullah Mahmud-Al-Rafat 2,4,✉
PMCID: PMC8200867  PMID: 26494479

Abstract

Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs. graphic file with name 12250_2015_3624_Figa_HTML.jpg

Keywords: dengue, epidemiology, pathogenesis, dengue vaccine, vector control, anti-viral, animal model

Footnotes

ORCID: 0000-0003-4263-125X

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