Tiina Kelkka
Tiina Kelkka
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,*,
Paula Savola
Paula Savola
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,†,
Dipabarna Bhattacharya
Dipabarna Bhattacharya
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,†,
Jani Huuhtanen
Jani Huuhtanen
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,†,
Tapio Lönnberg
Tapio Lönnberg
5
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
5,
Matti Kankainen
Matti Kankainen
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,4,
Kirsi Paalanen
Kirsi Paalanen
6
Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
6,
Mikko Tyster
Mikko Tyster
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,
Maija Lepistö
Maija Lepistö
7
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
7,
Pekka Ellonen
Pekka Ellonen
7
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
7,
Johannes Smolander
Johannes Smolander
5
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
5,
Samuli Eldfors
Samuli Eldfors
7
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
7,
Bhagwan Yadav
Bhagwan Yadav
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,
Sofia Khan
Sofia Khan
5
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
5,
Riitta Koivuniemi
Riitta Koivuniemi
8
Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
8,
Christopher Sjöwall
Christopher Sjöwall
9
Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden
9,
Laura L Elo
Laura L Elo
5
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
10
Institute of Biomedicine, University of Turku, Turku, Finland
5,10,
Harri Lähdesmäki
Harri Lähdesmäki
11
Department of Computer Science, Aalto University School of Science, Espoo, Finland
11,
Yuka Maeda
Yuka Maeda
12
Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan
12,
Hiroyoshi Nishikawa
Hiroyoshi Nishikawa
12
Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan
12,
Marjatta Leirisalo-Repo
Marjatta Leirisalo-Repo
8
Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
8,
Tuulikki Sokka-Isler
Tuulikki Sokka-Isler
6
Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
13
University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland
6,13,
Satu Mustjoki
Satu Mustjoki
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
1,2,3,4,*
1
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
5
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
6
Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
7
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
8
Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
9
Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden
10
Institute of Biomedicine, University of Turku, Turku, Finland
11
Department of Computer Science, Aalto University School of Science, Espoo, Finland
12
Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan
13
University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
✉*Correspondence: Satu Mustjoki, satu.mustjoki@helsinki.fi; Tiina Kelkka, tiina.kelkka@helsinki.fi
†These authors have contributed equally to this work
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
Received 2021 May 17; Accepted 2021 May 19; Collection date 2021.
Keywords: rheumatoid arthritis, seronegative, ACPA-negative, CD8+ lymphocyte, T cell receptor, somatic mutation
Copyright © 2021 Kelkka, Savola, Bhattacharya, Huuhtanen, Lönnberg, Kankainen, Paalanen, Tyster, Lepistö, Ellonen, Smolander, Eldfors, Yadav, Khan, Koivuniemi, Sjöwall, Elo, Lähdesmäki, Maeda, Nishikawa, Leirisalo-Repo, Sokka-Isler and Mustjoki
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