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. 2021 Jun 11;9:e11627. doi: 10.7717/peerj.11627

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©2021 Liang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) The Volcano plot of the differentially expressed ferroptosis-related genes. The red dots indicated up-regulated and blue for down-regulated. The top 20 gene symbols with high variation were displayed in the plot. (B) The heatmap of 20 ferroptosis-related genes with high variation in training cohort. (C) The heatmap of 20 ferroptosis-related genes with high variation (except for TUBE1, and FANCD2) between tumor and normal samples in validation cohort. (D) The GO circle plot of functional enrichment. The red dots indicated up-regulation, while the blue indicated down-regulation. (E) The KEGG circle plot of enrichment analysis. The Z-score was directly proportional to the level of enrichment.