Fig 2.

Subgroup analyses for primary endpoint of all cause death, myocardial infarction, or stroke in intention to treat population. High bleeding risk was defined on basis of PRECISE-DAPT score ≥25. *P value obtained by merging within study and across study interactions (owing to design of trials). †European regions pooled together and within study and across study interactions merged owing to trial designs. ACS=acute coronary syndrome; CABG=coronary artery bypass grafting; CAD=coronary artery disease; CKD=chronic kidney disease; DAPT=dual antiplatelet therapy; LAD=left anterior descending artery; P2Y12i=P2Y₁₂ inhibitor monotherapy; PCI=percutaneous coronary intervention