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. 2021 Mar 15;162(7):2070–2086. doi: 10.1097/j.pain.0000000000002207

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Activity prediction on plantar incision in iDRG on the network-level. Bioinformatic network analysis integrating DIA-MS data and multiplex Western blots (A) complemented with activity prediction (B). Note the prominent role of ERK signaling as a central hub among proteins associated with immune and inflammatory responses (from Fig. 3D). Node color code: red, regulated proteins based on DIA-MS; grey, predicted proteins based on multiplex Western blots; orange lines indicate predicted activation among nodes. All graphs are based on IPA analysis (for original IPA results, please see Figure, Supplement Digital Content 10, available at http://links.lww.com/PAIN/B274). DRG, dorsal root ganglia; DIA-MS, data-independent acquisition mass spectrometry; IPA, ingenuity pathway analysis.