Table 3.
Hazard ratios (95% CI) for lung cancer risk associated with the PRS of lung cancer, stratified by smoking status, UK Biobank, 2006–2016a
| PRS | Never smokers | Ever smokers | Current smokers | Former smokers |
|---|---|---|---|---|
| Q1 (lowest) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Q2 | 1.12 (0.67–1.89) | 1.18 (0.95–1.45) | 1.32 (0.98–1.77) | 1.04 (0.77–1.41) |
| Q3 | 1.24 (0.74–2.06) | 1.34 (1.01–1.52) | 1.17 (0.87–1.58) | 1.31 (0.98–1.74) |
| Q4 | 1.37 (0.83–2.24) | 1.42 (1.16–1.73) | 1.44 (1.08–1.92) | 1.40 (1.06–1.85) |
| Q5 (highest) | 1.93 (1.21–3.07) | 1.57 (1.29–1.91) | 1.55 (1.17–2.06) | 1.58 (1.21–2.08) |
| P for trend | 0.003 | <0.001 | 0.002 | <0.001 |
aHRs adjusted for sex, education, first 10 principal components, genotype array, pack-years (ever smokers only), and quit-time (former smokers only); P = 0.815 for interaction between never smokers and ever smokers; P = 0.778 for interaction across never, current and former smokers.