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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Neuropharmacology. 2021 May 11;192:108599. doi: 10.1016/j.neuropharm.2021.108599

Figure 5. GEP44 attenuates fentanyl seeking in rats.

Figure 5.

Rats were pretreated with vehicle or GEP44 prior to fentanyl and cue-primed reinstatement test sessions. Total active lever responses (A) and total number of infusions (B) were attenuated in rats pretreated with 0.3 and 2.4 nmol/kg GEP44 versus vehicle (n=13/treatment; *p<0.05, Bonferroni). (C) GEP44 did not affect 24-hour kaolin intake in rats during abstinence (n=13/treatment). (D) Cumulative chow intake was significantly decreased in rats pretreated with 2.4 nmol/kg GEP44 compared to vehicle-treated controls (n=13/treatment, *p<0.05, Bonferroni). Water intake (E) and body weight (F) were not altered in fentanyl-experienced rats (n=13/treatment) pretreated with GEP44 during abstinence.