Table 6.
Association between toxicity endpoints and variables of interest (N=100)2.
| Variable | Infusion reaction with any symptom, grade ≥ 3, OR (95% CI) |
Respiratory reaction, grade 3, OR (95% CI) |
Febrile reaction, grade 3, OR (95% CI) |
Cardiovascular reaction, grade ≥3, OR (95% CI) |
Headache, grade ≤ 3, OR (95% CI) |
Headache, grade 3, OR (95% CI) |
|---|---|---|---|---|---|---|
| NK cell dose (cells/kg, divided by 10,000,000) | 0.89 (0.57, 1.38) | 0.42 (0.13, 1.35) | 0.60 (0.29, 1.27) | 0.78 (0.43, 1.41) | 0.97 (0.55, 1.72) | 1.34 (0.63, 2.85) |
| Natural log of infusion rate (mL/min/kg) | 1.11 (0.43, 2.90) | 0.99 (0.12, 8.35) | 13.07 (1.81, 94.51) | 0.88 (0.28, 2.78) | 0.39 (0.12, 1.27) | 0.62 (0.11, 3.60) |
| Monocyte dose (cells/kg, divided by 10,000,000) | 1.60 (0.98, 2.61) | 2.37 (0.93, 6.02) | 0.69 (0.31, 1.54) | 2.13 (1.13, 3.99) | 2.17 (1.19, 3.97) | 1.49 (0.70, 3.18) |
| IL-2 vs IL-15 incubation | ||||||
| IL-2 | 2.63 (0.84, 8.23) | 6.18 (0.62, 61.77) | 3.65 (0.79, 16.90) | 5.89 (1.24, 27.95) | 0.25 (0.06, 1.11) | 0.64 (0.07, 5.78) |
| IL-15 | Reference | Reference | Reference | Reference | Reference | Reference |
| % viability (7-AAD) | 0.92 (0.80, 1.06) | 0.87 (0.72, 1.05) | 0.94 (0.78, 1.12) | 1.01 (0.86, 1.17) | 0.88 (0.74, 1.06) | 0.88 (0.69, 1.12) |
| Storage time (hours) | 1.27 (0.85, 1.89) | 1.54 (0.70, 3.37) | 1.41 (0.77, 2.59) | 1.76 (1.09, 2.85) | 0.70 (0.41, 1.20) | 0.70 (0.31, 1.58) |
| Diagnosis | ||||||
| AML, AML/myelofibrosis MDS & CMML | 1.47 (0.34, 6.34) | 1.03 (0.06, 16.87) | N.E.3 | 1.05 (0.22, 4.98) | 0.33 (0.05, 2.09) | 0.62 (0.04, 10.35) |
| BrCa, Ovarian Cancer & PAC | 1.08 (0.19, 6.02) | 0.67 (0.03, 14.38) | N.E.3 | 0.31 (0.04, 2.36) | 0.71 (0.11, 4.66) | 2.82 (0.21, 38.70) |
| CLL & NHL | Reference | Reference | Reference | Reference | Reference | Reference |
| Patient age (decades) | 0.92 (0.69, 1.22) | 1.26 (0.67, 2.39) | 1.39 (0.86, 2.24) | 1.43 (0.93, 2.20) | 0.66 (0.47, 0.93) | 0.69 (0.43, 1.10) |
1
Multivariable logistic regression was performed for six outcomes to investigate the association between these outcomes and variables of interest. Odds ratios and 95% CIs are presented for each variable. CIs are bolded if they do not include 1.0.
2
Final sample size for all models is 100 due to missing independent variables.
3
N.E. indicates not estimable due to cell counts of 0.