Table 4.

AKR1B10-upregulated chemoresistant cancer cells.

Cell		Drug *	Suggested Role of AKR1B10	References
CRC	HT29 cell	L-OHP	Promotion of cell proliferation by modulating isoprenoid metabolism.	[55]
	HT29 cell	MMC	Detoxification of RCS and drug metabolism	[143]
	Lovo cell	CDDP	Detoxification of RCS and down-regulation of PPARγ	[103]
	Lovo cell	DOX	Autophagy suppression by detoxification of RCS	[144]
Gastric cancer MKN45 cell		CDDP	Detoxification of RCS and down-regulation of PPARγ	[103]
		DOX	Detoxification of RCS and elevation of migrating and invasive potentials through MMP2 induction	[18]
Lung cancer A549 cell		CDDP	NO production by detoxification of RCS	[48]
		DTX	Detoxification of RCS	[145]
Breast cancer MCF-7 cell		DOX	Drug metabolism	[146]
Prostate cancer Du145 cell		DTX	Detoxification of RCS	[145]
Medulloblastoma D341 MED cell		CPA	Metabolism of a reactive metabolite, aldophosphamide	[147]

Note: * Abbreviations: L-OHP, oxaliplatin; MMC, mitomycin c; CDDP, cisplatin; DOX, doxorubicin; DTX, docetaxel; CPA, cyclophosphamide.