Table 5.
Report characteristics and H. pylori infection rates in the laryngeal tissues (in chronological order).
| First Author (Year) | Country | Sample Type | Detection Methods | Study Design | H. pylori Infection Rate in the Laryngeal Lesions | Level of Evidence | ||
|---|---|---|---|---|---|---|---|---|
| Laryngeal Cancer | Controls | p-Value | ||||||
| Akbayir N (2005) [49] | Turkey | FFPE | H/IHC | CCS | 0% (0/50) | 0% (0/50) | >0.99 | 3 |
| Kizilay A (2006) [50] | Turkey | FFPE | H | CCS | 0% (0/90) | 0% (0/30) | >0.99 | 3 |
| Titiz A (2008) [51] | Turkey | FF | PCR | CCS | 81% (17/21) | 0% (0/19) | <0.001 | 3 |
| Masoud N (2008) [59] | Iran | F/FFPE | RUT/H | CCS | 0% (0/44) | 0% (0/30) | >0.99 | 3 |
| Grbesa I (2008) [52] | Croatia | FF | PCR | CS | 26% (9/35) | NA | NA | 4 |
| Shi Y (2011) [53] | China | FF | PCR | CCS | 76% (45/59) | 32% (13/41) | <0.001 | 3 |
| Gong H (2012) [20] | China | FF | PCR | CCS | 72% (58/81) | 25% (19/75) | <0.001 | 3 |
| Siupsinskiene N (2013) [54] | United States | F | RUT | CS | 46% (6/13) | 9% (1/11) | 0.047 | 4 |
| Burduk PK (2013) [55] | Poland | F | PCR | CS | 47% (35/75) | NA | NA | 4 |
| Genç R (2013) [21] | Turkey | FFPE | IHC | CCS | 0% (0/31) | 0% (0/28) | >0.99 | 3 |
| Fellmann J (2014) [16] | Switzerland | FFPE | PCR | CS | 50% (2/4) | 25% (1/4) | 0.47 | 4 |
| Amizadeh M (2015) [56] | Iran | FF | PCR | CCS | 33% (24/72) | 46% (33/72) | 0.13 | 3 |
| Yilmaz I (2016) [57] | Turkey | FFPE | PCR | CS | 1% (1/74) | NA | NA | 4 |
| Barakat G (2016) [58] | Egypt | F | PCR | CCS | 59% (29/49) | 7% (1/15) | <0.001 | 3 |
| Pajić Matić I (2018) [12] | Croatia | FFPE | H/PCR | CS | 14% (7/51) | NA | NA | 4 |
| This study (2021) | Taiwan | FFPE | PCR/IHC | CS | 0% (0/46)/2% (1/46) | 3% (1/37)/3% (1/37) | 0.26 | 4 |
| Total 1 | 29.4% (234/795) | 16.7% (69/412) | ||||||
Abbreviations: CCS: case-controlled study; CS: case-series; F, fresh samples; FF, fresh-frozen samples; FFPE, formalin-fixed paraffin-embedded samples; H, histopathology; H. pylori, Helicobacter pylori; IHC, immunocytochemistry; NA, not available; PCR, polymerase chain reaction; RUT, rapid urease test. 1 Result of a pooled data analysis. Significant p-values are marked in bold.