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Physiological changes of parameters associated with hepatic impairment.
| Parameter | Control Group | Mild Hepatic Impairment | Moderate Hepatic Impairment |
|---|---|---|---|
| Hematocrit value b | 0.47 a | 0.39 b | 0.37 b |
| Blood flow b | |||
| portal | 1.00 | 0.40 | 0.36 |
| renal | 1.00 | 0.88 | 0.65 |
| hepatic arterial | 1.00 | 1.30 | 2.30 |
| other organs | 1.00 | 1.75 | 2.25 |
| Liver volume fractionb | 1.00 | 0.81 | 0.65 |
| CYP3A4 activity | 1.00 | 1.00 | 0.40 |
| Plasma protein scale factor | 1.00 a | 0.85 | 1.25 |
a value based on PKSim®, b values according to Edginton et al. [38].
