Table 4.

Effects of aspartame in various diseases.

Type of Disease	Influence of Aspartame
Obesity	It is unclear if obesity is associated with the consumption of products containing aspartame.
Diabetes mellitus	The connection between aspartame and TD2 risk is unclear.
Impact on children and fetus	Aspartame may have influence on children and fetuses.
Genotoxicity	Aspartame may have genotoxic properties.
Behavioral disorders	Aspartame can cause long-term changes in behavior.
Autism	Aspartame itself does not trigger autism.
Neurodegeneration	Aspartame cause mental stress, affects learning skills and memory. Aspartame is also amyloidogenic.
Neurotransmission	Aspartame reduces catecholamine levels.
Hormones	Aspartame elevates plasma corticosterone level and plasma adrenocorticotropic level.
Allergies and skin problems	Aspartame can induce systemic contact dermatitis (in huge daily doses which leads to formaldehyde accumulation). 0.5 μg kg−1 and 0.5 mg kg−1 doses of aspartame reduces some atopic dermatitis symptoms.
Phenylketonuria	Aspartame intake rises plasma Phe level. People suffering from phenylketonuria should avoid products containing aspartame.
Cancer	Aspartame may have carcinogenic properties but further studies are needed.