Figure 8.

Ginsenoside CK blocked the EMT in HCC cells through suppressing the HIF-1α signaling and NF-κB signaling pathway in vivo. (A) Western blotting of HIF-1α, EMT markers, cytokines, metastasis related protein and NF-κB signaling in HCC-LM3 xenograft tumor specimens. The results shown were representative of three independent experiments. (B) IHC staining of HIF-1α, N-cadherin and Vimentin in HCC-LM3 xenografts. Magnification 400×. (C) Tumor specimens from the xenograft were immunohistochemically stained with anti-IκBα and anti-p-IκBα antibody. Magnification 400×.