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. 2021 Jun 2;13(6):1914. doi: 10.3390/nu13061914

Table 3.

Vitamins in the prevention of the muscle atrophy in vitro/vivo.

Vitamins Structure Example Source Inducer Model Effect Mechanism Ref
Vitamin C graphic file with name nutrients-13-01914-i009.jpg Kiwi fruit, lemons Senescence marker protein-30-konckout Mice ↑ Physical performance ↓ MuRF1, MAFbx
↓ Oxidative stress
[56]
Vitamin D graphic file with name nutrients-13-01914-i010.jpg Milk, meat Immobilization C57BL/6 mice ↑ Muscle mass ↓ Oxidative stress
↓ MuRF1, MAFbx
[60]
Vitamin E graphic file with name nutrients-13-01914-i011.jpg Soybean oil Immobilization Wistar rats / ↓ Oxidative stress [62]
Aging Human ↑ Muscle mass/strength / [63]
β-Carotene graphic file with name nutrients-13-01914-i012.jpg Carrot Denervation ddY mice ↑ Muscle mass ↓ Oxidative stress
↓ MuRF1, MAFbx, USP14, USP19
[65]
Coenzyme Q10 graphic file with name nutrients-13-01914-i013.jpg Sardine Disuse SD rats ↑ Muscle cross section ↑ Mitochondrial biogenesis
↓ MuRF1, MAFbx, FoxO3
[68]
Nicotinamide mononucleotide graphic file with name nutrients-13-01914-i014.jpg Broccoli, avocado Aging C57BL/6N ↑ Physical performance ↑ Mtochondrial oxidative metabolism [70]

Abbreviation: MAFbx, Muscle atrophy F-box; MuRF1, Muscle RING-finger protein-1; USP 14, Ubiquitin-specific processing protease 14; USP 19, Ubiquitin-specific processing protease 19; FoxO3, Forkhead box O3; ↑, Increase or promote; ↓, Decrease or inhibit.