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. 2021 May 29;11(6):808. doi: 10.3390/biom11060808

Figure 1.

Figure 1

Efficient inhibition of viral replication upon Pictilisib treatment. (a–d) NCl-H441 cells (a,b), A549 cells (c) or Calu-3 cells (d) were pre-incubated with the indicated concentrations of Pictilisib or solvent control (DMSO) for 30 min prior to infection. Afterwards, viral infection was performed with PR8M (H1N1) for 8 h (MOI 0.5) (a), 24 h (MOI 0.01) (b), (MOI 0.5) (d), or SC35M (H7N7; MOI 0.001) for 20 h (c) in the presence of the indicated concentrations of Pictilisib or DMSO. Data represent means + SD of three independent experiments including two (a,b,d) or four (c) biological samples. DMSO-treated cells were arbitrarily set as 100%. Statistical analysis was performed by one-way ANOVA followed by multiple comparisons test. (**** p < 0.0001, *** p < 0.001, ** p < 0.01).