Table 2.
Polyphenols-mediated beneficial outcomes and pathways following Ischemic Stroke.
| Treatment | Human | Animal | Effect | Reference |
|---|---|---|---|---|
| Pomegranate polyphenols | X | ↑ Cognitive and functional parameters | [92] | |
| Resveratrol, or EGCG, or Fisetin | X | ↑ Therapeutic window ↑ NIHSS scores ↓ MMP-2 and MM-9 levels |
[95,96,97,98] | |
| Salvianolic acid | X | ↑ Behavioural tests ↑ Shh pathway leading to neurogenesis ↑ Angiogenesis mediated by JAK2/STAT3 pathway |
[99] | |
| Resveratrol | X | ↓ Neurological deficits ↓ Cerebral edema ↓ Inflammation ↑ Th2 anti-inflammatory response |
[100,101] |
↑ = increase and improve; ↓ = reduce.