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IDA loading efficiency with different loading methods (n = 3). The results of screening the amount of drug to add in three CalliSpheres® of different particle sizes: (A) 50–150 μm; (B) 100–300 μm; and (C) 300–500 μm. The results of further loading method screening: (D) loading medium; (E) loading condition; and (F) drug concentration. The IDA loading curves by the optimized loading method are shown (G). The results of ultimate loading test are shown (H).
