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. 2021 Jun 11;26(12):3577. doi: 10.3390/molecules26123577

Figure 7.

Figure 7

Duration of the antihyperalgesic effect of single-dose minocycline and duloxetine, each used alone, on the pain threshold in oxaliplatin-treated mice. Effect of minocycline (50, 100 mg/kg, i.p.) on cold hyperalgesia measured in the cold plate test assessed 1 h, 4 h, 6 h and 12 h after administration, on the day of oxaliplatin administration (A) and 7 days later (B). Effect of duloxetine (10, 30 mg/kg, i.p.) on cold hyperalgesia measured in the cold plate test assessed 1 h, 4 h, 6 h and 12 h after administration, on the day of oxaliplatin administration (C) and 7 days later (D). The results are shown as the mean latency to pain reaction ± SEM for n = 10. Statistical analysis: repeated measures ANOVA followed by Tukey’s post-hoc comparison. Significance: ### p < 0.001, #### p < 0.0001 vs. latency before oxaliplatin; * p < 0.05, *** p < 0.001 vs. pre-drug latency to pain reaction. Abbreviations: MI—minocycline, DL—duloxetine. In the figure titles ‘early phase’ (A,C) and ‘late phase’ (B,D) mean two time points at which the measurements were taken (day of oxaliplatin administration and day 7 after a single-dose oxaliplatin administration, respectively). Numerical values of the latencies to pain reaction ± SEM presented in this figure are shown in the Supplementary Materials (Table S4).