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. Author manuscript; available in PMC: 2021 Aug 12.
Published in final edited form as: J Am Chem Soc. 2020 Jul 27;142(32):13677–13682. doi: 10.1021/jacs.0c06179

Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones

Xinpei Cai 1, Weida Liang 1, Mingxin Liu 1, Xiating Li 1, Mingji Dai 1,*
PMCID: PMC8232350  NIHMSID: NIHMS1713817  PMID: 32687339

Abstract

A novel palladium-catalyzed ring opening carbonylative lactonization of readily available hydroxycyclopropanols was developed to efficiently synthesize tetrahydrofuran (THF) or tetrahydropyran (THP)-fused bicyclic γ-lactones, two privileged scaffolds often found in natural products. The reaction features mild reaction conditions, good functional group tolerability, and scalability. Its application was demonstrated in a short total synthesis of (±)-paeonilide. The fused bicyclic γ-lactone products can be easily diversified to other medicinally important scaffolds, which further broadens the application of this new carbonylation method.

Graphical Abstract

graphic file with name nihms-1713817-f0001.jpg

Nature has been constantly creating natural products with novel, diverse, and complex structures. Many of these natural products or their derivatives have been used as medicines to treat human diseases or are lead compounds for drug discovery.1 While various biosynthetic pathways and different organisms are involved in natural product production, privileged structural scaffolds shared by a large number of natural products can often be identified.1c Cis-2,8-dioxabicyclo[3.3.0]octan-3-one (a THF-fused bicyclic γ-lactone, also called cis-tetrahydro[2,3-b]furan-2(3H)-one) is one such privileged structural scaffold, which has been found in over 100 natural products from various origins (Figure 1).2 In these molecules, the THF-fused γ-lactone forges diverse connections with the rest of the molecular structures. Part of them such as ginkgolide B (1a),3 gracilin B (1b),4 paracaseolide A (1c),5 and darwinolide (1d),6 have the bicyclic γ-lactone moiety embedded in a large polycyclic ring system. Another portion of them including norrisolide (1e)7 and cheloviolene A (1f)8 have the bicyclic γ-lactone connected with a second (poly)cyclic ring system via a C-C single bond. Why and how nature produces such fused bicyclic skeletons are yet to be understood. Natural products with such a bicyclic γ-lactone motif have demonstrated a wide range of biological activity and possess great potential in novel therapeutic development. For example, the ginkgolides can act as anti-platelet-activating factors; gracilins exhibit immunosuppressive and neuroprotective properties; paracaseolide A inhibits phosphatase CDC25B, an emerging and important target for anticancer drug discovery; the marine spongian diterpenoid norrisolide and its analogs demonstrated unique Golgi-modifying activity; darwinolide is a biofilm-penetrating anti-MRSA agent. Additionally, the related cis-2,9-dioxabicyclo[4.3.0]nonan-8-one (a THP-fused bicyclic γ-lactone, also called cis-tetrahydro-4H-furo[2,3-b]pyran-2(3H)-one) has been found in natural products,9 including applanatumol B (1h),9a which showed activity against renal fibrosis.

Figure 1.

Figure 1.

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Selected natural products with a THF/THP-fused bicyclic γ-lactone

Due to their unique and challenging chemical structures as well as their diverse biological applications, natural products with a THF/THP-fused bicyclic γ-lactone moiety have been popular targets in total synthesis practices.10 Notably, the Overman group recently accomplished elegant total syntheses of several marine spongian diterpenoids including cheloviolene A (1f, Figure 1) with a THF-fused γ-lactone.11 So far, most of these total syntheses utilized the hydroxy-acid-aldehyde (or their masked forms) condensation reactions to construct the desired THF/THP-fused γ-lactone moiety in the target molecules (eq. A-1, Figure 2A). In these processes, tedious functional group manipulations, protections, and deprotections are often involved, which added extra steps to the entire synthesis. Surprisingly, synthetic methodology development in this area is extremely barren.12 Notably, Trost and Toste developed a Pd-catalyzed asymmetric nucleophilic substitution of 5-aceloxy-2-(5H)-furanone followed by reductive intramolecular Heck reaction to build THF-fused γ-lactones,12a but this method is limited to benzo-fused tricyclic systems (eq. A-2). Theodorakis12b and Reiser12c independently reported elegant activated cyclopropane rearrangements to THF-fused γ-lactones (eq. A-3). In the Reiser’s case, the activated cyclopropanes were generated via Rh-catalyzed enantioselective cyclopropanation of furans. In general, these prior arts are limited to 5,5-fused γ-lactones and hydrogen atom substitution at the ring junction carbons. Thus, versatile, modular, and catalytic methods are highly desirable.

Figure 2.

Figure 2.

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Synthetic methodology design

We recently developed a Pd-catalyzed hydroxycyclopropanol ring opening carbonylative lactonization to synthesize oxaspirolactones, another privileged scaffold frequently appears in natural products (2→5, Figure 2B).13 This new synthetic capability significantly facilitated our total syntheses of C12 oxygenated diterpenes and Stemona alkaloids.14 With this success, we wondered the possibility of developing a catalytic carbonylation chemistry to prepare THF/THP-fused γ-lactones with various substitution patterns (Figure 2C). To achieve this goal, cyclopropanols such as 6 would be required. They can be convergently assembled from readily available ester 7 and homoallylic alcohol 8 using the cyclopropanol synthesis15 protocol developed by Cha and co-workers.16 We envisioned a process involving Pd-catalyzed β-carbon elimination to generate Pd-homoenolate 9. Ideally, we hoped for an acetal formation followed by carbonylative lactonization to convert 9 to desired fused bicyclic γ-lactone 11, presumably via an intermediate like 10. In principle, several processes could compete with the desired one. For instance, β-hydride elimination would decompose 9 to an enone; the tethered secondary alcohol could attack the Pd center and a following C-O reductive elimination would give THF product 12. Additionally, carbonylative lactonization with the same tethered alcohol would give δ-lac-tone 14 (9→13→14). At the planning stage, we didn’t know which pathway would dominate, but it would be ideal to develop conditions to access 11, 12, or 14 at wish. We were particularly attracted by the conversion of hydroxycyclopropanol 6 to fused lactone 11. The established modular assembly of 6 would enable the introduction of various substitutions in product 11, especially at the ring junction carbon where the R group resides. Meanwhile, we were hoping that the use of bishomoallylic alcohols may eventually result in THP-fused γ-lactones. Given the prevalence of THF/THP-fused γ-lactones in biologically active natural products, this chemistry is expected to find broad application in facilitating the chemical syntheses of those natural products and their analogs. Herein, we report such a Pd-catalyzed hydroxycyclopropanol ring opening carbonylative lactonization to the aforementioned bicyclic γ-lactones and its application in a short total synthesis of (±)-paeonilide (1g) and other medicinally important bicyclic and polycyclic scaffolds.

Our investigation started with known hydroxycyclopropanol 15a (Table 1).16 When it was subjected to the carbonylative spirolactonization conditions we developed before with ([Pd(neoc)(OAc)]2(OTf)2 as catalyst and 1,4-benzoquinone (BQ) as oxidant,13 the formation of 16a was not observed (entry 1). Switching [Pd(neoc)(OAc)]2(OTf)2 to palladium(II) trifluoroacetate (Pd(TFA)2) was not fruitful either (entry 2). The break-through came by using Cu(OTf)2 to replace BQ as the oxidant, which resulted in the formation of 16a in 6% yield (entry 3). The structure of 16a was unambiguously confirmed by X-ray crystallographic analysis.17 The use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant increased the yield to 18% (entry 4). Further investigation of palladium catalysts led to the identification of Pd(OAc)2 as an optimal choice (entry 5-6). Other 1,4-benzoquinone derivatives including 2,5-DMBQ and 2,6-DMBQ were not effective (entry 8, 9). THF (entry 7), toluene (entry 10), and benzene (entry 14) were suitable solvents with benzene giving slightly better yield (also see 16e and 16n, Table 2). Elevating reaction temperature (40 °C, entry 11) or increasing the amount of DDQ (entry 12) led to reduced reaction yield. Finally, reducing the reaction concentration from 0.03 M to 0.01 M was beneficial and product 16a was obtained in 74% yield (entry 14). The reaction is also scalable. Scaling up the reaction from 0.2 mmol to 2.92 mmol led to the formation of 16a in 65% yield. Moreover, when enantioenriched homoallylic alcohol (1-phenylbut-3-en-1-ol, 92% ee) was used, 16a was obtained in 92% ee (73% yield) after a sequence of cyclopropanol formation and carbonylative lactonization. Given the ready availability of enantioenriched homoallylic alcohols, our method offers an efficient asymmetric alternative to THF-fused γ-lactones.

Table 1.

Reaction condition optimizationa

graphic file with name nihms-1713817-t0007.jpg
entry reaction conditions yieldb
1 [Pd(neoc)(OAc)]2(OTf)2, BQ, DCE (0.03), rt 0%
2 Pd(TFA)2, BQ, DCE (0.03), rt 0%
3 Pd(TFA)2, Cu(OTf)2, DCE (0.03), rt 6%
4 Pd(TFA)2, DDQ, DCE (0.03), rt 18%
5 PdCl2, DDQ, DCE (0.03), rt 0%
6 Pd(dppf)Cl2, DDQ, DCE (0.03), rt trace
7 Pd(OAc)2, DDQ, THF (0.03), rt 58%
8 Pd(OAc)2, 2,5-DMBQ, THF (0.03), rt trace
9 Pd(OAc)2, 2,6-DMBQ, THF (0.03), rt trace
10 Pd(OAc)2, DDQ, toluene (0.03), rt 65%
11 Pd(OAc)2, DDQ, toluene (0.03), 40 °C 51%
12 Pd(OAc)2, DDQ (3.0 equiv.), toluene (0.03), rt 58%
13 Pd(OAc)2, DDQ, toluene (0.01), rt 70%
14 Pd(OAc)2, DDQ, benzene (0.01), rt 74%c,d
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[a]

General reaction conditions: To a stirred solution of 15a (1.0 equiv., 0.2 mmol) and DDQ (2.0 equiv.) in benzene (0.01 M) under carbon monoxide (balloon) was added Pd(OAc)2 (0.1 equiv.) in one portion. The resulting solution was stirred at room temperature until no more starting material left. The reaction process was monitored by thin-layer chromatography

[b]

Isolated yield

[c]

65% for 0.56-gram scale (2.92 mmol)

[d]

73% yield and 92% ee when 15a was prepared from the corresponding enantioenriched homoallylic alcohol with 92% ee; 2,5-DMBQ: 2,5-dimethylbenzoquinone; 2,6-DMBQ: 2,6-dimethylbenzoquinone.

Table 2.

Substrate scope

graphic file with name nihms-1713817-t0008.jpg
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We then evaluated the scope and generality of this new Pd-catalyzed hydroxycyclopropanol ring opening carbonylative lactonization. The reaction proved to be very robust. A variety of hydroxycyclopropanol substrates could be transformed into the corresponding cis-fused bicyclic γ-lactones. THF-fused γ-lactone products with either an aryl or an alkyl group at the C5-position could be obtained. Notably, tosylate (16e), TBS-ether group (16k, 16l, 16s), and heteroaromatics including indole (16g), furan (16h), thiophene (16i), and pyrrole (16j) are all tolerated under the mild reaction conditions. Substrates containing sterically hindered secondary (16m) and tertiary alcohols (16n, 16o, 16p, 16q) were effective as well. Most of the previously reported methods are limited to have hydrogen atom at C6 of the ring junction. In our case, the substituent at this position can be altered from a methyl group to a hydrogen (16w) or other bulkier alkyl groups including cyclohexyl and isopropyl groups (16r, 16s, 16t, 16u, 16v, 16x, and 16y). Variation of the stereochemistry of the secondary alcohol on the side chain was tolerated as well (cf. 16x vs 16y). Similar reaction yields were obtained, but the reaction of 16y took longer time. Furthermore, THP-fused γ-lactones could be produced in modest to good yield (16za, 16zb, 16zc, and 16zd). Additionally, slow addition of DDQ to the reaction mixture could be beneficial to improve the reaction yield (cf. 16c and 16d), but was not employed to all the substrates due to the operational inconvenience.

We also evaluated hydroxycyclopropanol 17, which could undergo ring opening carbonylation to form either fused γ-lactone 21 or spirolactone 22 presumably via intermediate 19 or 20, respectively (Scheme 1). Both 19 and 20 could be derived from the same palladium-homoenolate 18. When 17 was subjected to the optimized carbonylative conditions (entry 14, Table 1), fused γ-lactone 21 was obtained in 47% yield without any spirolactone 22 formation. Interestingly, even when the carbonylative spirolactonization conditions were used ([Pd(neoc)(OAc)]2(OTf)2 and BQ),13 fused lactone was still the dominant product, but in lower yield.

Scheme 1.

Scheme 1.

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A “competition” case

We next decided to test this new carbonylative lactonization method in natural product total synthesis and chose paeonilide (1g) as our initial target. Paeonilide is a monoterpenoid isolated from Paeonia delavayi by Liu and co-workers.18 It selectively inhibits platelet aggregation induced by platelet activating factor and has been previously synthesized by the groups of Zhang (chiral pool synthesis starting from (R)-(-)-carvone, 14 LLS steps;19a racemic, 17 LLS steps19b), Du (racemic, 6 LLS steps),19c Reiser (enantioselective, 12 LLS steps),19d and Argade (racemic, 11 LLS steps)19e from commercially available starting materials. Our synthesis started with known compounds 2320 and 24,21 which were prepared in one and three steps, respectively, from commercially available starting materials. They were united via a Kulinkovich reaction to give desired hydroxycyclopropanol 25, albeit in low yield due to the existence of the ketal, free alcohol, and primary TBS ether. When 25 was subjected to the carbonylative lactonization conditions, bicyclic γ-lactone 26 was produced in 42% yield (99% yield brsm). Removal of the TBS and ketal protecting groups under acidic conditions followed by benzoate formation completed the total synthesis (±)-paeonilide in 4 LLS steps in 3.6% yield from known compounds 23 and 24 or 7 LLS steps from commercially available starting materials.

Additionally, the fused bicyclic lactone product can be diversified to other medicinally important structural scaffolds (Scheme 3). α-Methylene γ-butyrolactone is another privileged scaffold frequently found in natural products22 Treatment of 16a with the Bredereck’s reagent followed by DIBAL-H reduction23 could convert 16a to α-methylene γ-butyrolactone containing bicyclic product 28 in high yield. The lactone moiety of 16a could also be converted to a lactam (cf. 30) via the treatment of MeNH2 followed by acid-promoted cyclization. Aldol reaction of 16a with benzaldehyde gave a 3:1 mixture of diastereomers in 82% yield. The relative stereochemistry of the major product 31 was established by X-ray crystallographic analysis of its p-bromobenzoate derivative 32.17 Hexahydrofuro[2,3-b]furan is an important scaffold in protease inhibitors, including the FDA-approved anti-HIV drug Darunavir (34).24 Bicyclic lactone 16a could be readily converted to hexahydrofuro[2,3-b]furan-containing product 33 via a sequential DIBAL-H and triethylsilane reduction process. Furthermore, 16a could also be elaborated to tricyclic products 36 and 37 via a series of standard functional group manipulations.25 These two tricyclic scaffolds have been found in natural products such as gracilin B (1b) and potent protease inhibitors including GRL-0519A.26 These diversification pathways demonstrate the potential broad application of the newly developed carbonylative lactonization method.

Scheme 3.

Scheme 3.

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Synthetic diversifications.

In summary, we have developed a novel Pd-catalyzed hydroxycyclopropanol ring opening carbonylative lactonization to synthesize THF/THP-fused bicyclic γ-lactones. This method features mild reaction conditions, good functional group tolerability, and scalability. Its application was demonstrated in a short total synthesis of racemic paeonilide. The bicyclic lactone products could be further elaborated to other valuable structures.

Supplementary Material

Supplementary Material

Scheme 2.

Scheme 2.

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Total synthesis of (±)-paeonilide

ACKNOWLEDGMENT

This work was financially supported by NSF CAREER Award 1553820. The NIH P30 CA023168 is acknowledged for supporting shared NMR resources to Purdue Center for Cancer Research. The XRD data is collected on a new single crystal X-ray diffractometer supported by the NSF through the Major Research Instrumentation Program under Grant No. CHE 1625543.

Footnotes

Supporting Information

The Supporting Information is available free of charge on the ACS Publications website.

Experimental procedures and spectra data (PDF file)

Cystallographic data for 16a and 32 (cif file)

The authors declare no competing financial interest.

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