Abstract
We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic ОН· radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity.
Key Words: selenium; Fenton system; malondialdehyde (MDA); 2’,7’-dichlorofluorescein; liver cells
Footnotes
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 2, pp. 214-218, February, 2021
References
- 1.Gorozhanskaya EG, Sviridova SP, Dobrovolskaya MM, Zubrikhina GN, Kashiya SR. Selenium and oxidative stress in cancer patients. Biomed. Khimiya. 2013;59(5):550–562. doi: 10.18097/pbmc20135905550. [DOI] [PubMed] [Google Scholar]
- 2.Dzikovskaya LA, Erimbetov KT, Grosheva IP, Bondarenko EV, Goncharova AY. Oxidant Potential of Krunidon In Vitro and In Vivo. Bull. Exp. Biol. Med. 2018;166(2):213–216. doi: 10.1007/s10517-018-4316-2. [DOI] [PubMed] [Google Scholar]
- 3.Ipatova OM, Torkhovskaya TI, Medvedeva NV, Prozorovsky VN, Ivanova ND, Shironin AV, Baranova VS, Archakov AI. Bioavailability of oral drug formulations and the methods for its improvement. Biochemistry (Moscow) Suppl. Series B: Biomedical Chemistry. 2010;4(1):82–94. [Google Scholar]
- 4.Nikitin NA. Cyclodextrins and their inclusion complexes (review). Vopr. Biol., Med. Farm. Khimii. 2015;(6):3-11. Russian.
- 5.Podgorodnichenko VK, Tsyb AF, Roziev RA, Goncharova AJ, Vorob’ev IV, Erimbetov KT. Patent RU No. 2451680. Clatrate complex of cyclodextrine or arabinogalactane with 9-phenylsymm-octahydroselenoxantene, its production method (versions), pharmaceutical composition and medication. Bull. No. 15. Published May 27, 2012.
- 6.Poluboyarinov PA, Elistratov DG, Shvets VI. Metabolism and mechanism of toxicity of selenium-containing supplements used for optimizing human selenium status. Tonkie Khim. Tekhnol. 2019;14(1):5-24. 10.32362/2410-6593-2019-14-1-5-24. Russian.
- 7.Ryabchenko NI, Ivannik BP, Ryabchenko VI, Degtyaryova ES, Dzikovskaya LA, Sinkova RV. Influence of Ionizing Radiation on the Parameters of Oxidative Stress Markers in the Rat Liver and Thymus. Radiats. Biol. Radioekol. 2013;53(3):229–235. doi: 10.7868/S0869803113030119. [DOI] [PubMed] [Google Scholar]
- 8.Tutelyan VA, Knyazhev VA, Khotimchenko SA. Golubkina NA. Sokolov JA. Selenium in the Human body. Metabolism. Antioxidant Properties, Role in Carcinogenesis. Moscow: Kushlinskii NE; 2002. [Google Scholar]
- 9.Brubacher JL, Bols NC. Chemically de-acetylated 2,7-dichlorodihydrofluorescein diacetate as a probe of respiratory burst activity in mononuclear phagocytes. J. Immunol. Methods. 2001;251(1-2):81–91. doi: 10.1016/s0022-1759(01)00308-8. [DOI] [PubMed] [Google Scholar]
- 10.Cheng CS, Wang N, FengY. Selenium in the prevention and treatment of hepatocellular carcinoma: from biomedical investigation to clinical application. Selenium in the environment and human health. IntechOpen, 2019. 10.5772/intechopen.88960
- 11.Gupta S, Read SA, Shackel NA, Hebbard L, George J, Ahlenstiel G. The role of micronutrients in the infection and subsequent response to hepatitis C virus. Cells. 2019;8(6):603. doi: 10.3390/cells8060603. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Mitra A, Mandal S, Das P, Dasgupta S, Mukhopadhyay S, Mukhopadhyay A, Banerjee J, Kar M. Antioxidant and free radical scavenging properties of seed components of Pongamia pinnata — a comparative study. Organic Med. Chem. IJ. 2018;7(5):555723. 10.19080/OMCIJ.2018.07.555723
- 13.Yang B, Wang D, Wei G, Liu Z, Ge X. Selenium-enriched Candida utilis: efficient preparation with l-methionine and antioxidant capacity in rats. J. Trace Elem. Med. Biol. 2013;27(1):7–11. doi: 10.1016/j.jtemb.2012.06.001. [DOI] [PubMed] [Google Scholar]
- 14.Zhang J, Taylor EW, Bennett K, Saad R, Rayman MP. Аssociation between regional selenium status and reported outcome of COVID-19 cases in China. Am. J. Clin. Nutr. 2020;111(6):1297–1299. doi: 10.1093/ajcn/nqaa095. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Zhao L, Zhao G, Du M, Zhao Z, Xiao L, Hu X. Effect of selenium on increasing free radical scavenging activities of polysaccharide extracts from a Se-enriched mushroom species of the genus Ganoderma. Eur. Food Res. Technol. 2008;226:499–505. doi: 10.1007/s00217-007-0562-7. [DOI] [Google Scholar]