Abstract
The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host’s antiviral immune response.
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Funding note: Open Access funding enabled and organized by Projekt DEAL.
Footnotes
Danksagungen
Die Autoren danken allen an der Studie beteiligten Wissenschaftlern, insbesondere Roland Beckmann und seiner Gruppe (LMU München).
Frank Kirchhoff Biologiestudium an der Universität Göttingen. 1991 Promotion. 1991–1994 Postdoc am New England Primate Research Center, Harvard Medical School, Boston, USA. 1994–2001 Arbeitsgruppenleiter am Lehrstuhl für Virologie, Universität Erlangen-Nürnberg. 2001–2009 Professor und Arbeitsgruppenleiter am Institut für Virologie und seit 2009 Direktor des Instituts für Molekulare Virologie am Universitätsklinikum Ulm.
Konstantin Sparrer 2005–2010 Studium der Chemie und Biochemie an der LMU München. 2013 Promotion. 2013–2014 Postdoktorand am Max von Pettenkofer-Institut, München. 2015–2017 Postdoktorand an der Harvard Medical School, Boston, MA, und University of Chicago, IL, USA. Seit 2018 Juniorgruppenleiter am Institut für Molekulare Virologie am Universitätsklinikum Ulm.
Contributor Information
Konstantin Sparrer, Email: Konstantin.Sparrer@uni-ulm.de.
Frank Kirchhoff, Email: Frank.Kirchhoff@uni-ulm.de.
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