Abstract
Posttranscriptional regulation at mRNA level is defined not only by sequence, but also by the structure of the mRNA. Structures in the untranslated regions control stability, translation and localization of an mRNA. Evolutionary conservation can be used to identify such regulatory active structures in mRNAs. For example, constitutive decay element (CDE) stem-loops are recognized by Roquin proteins in an exclusively shape-specific manner. Strikingly, some CDEs can serve a dual function in gene repression depending on their folding status.
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Funding note: Open Access funding enabled and organized by Projekt DEAL.
Footnotes
Chiara Lichtenthaeler 2014–2017 Biowissenschaftenstudium an der Universität Frankfurt a. M. 2017–2020 Molekulare-Medizin-Studium an der Universität Frankfurt a. M. Seit 2020 Promotion am Fachbereich Biologie der TU Darmstadt im Labor von PD Dr. J. Weigand.
Lasse Oberstrass 2008–2012 Ausbildung als CTA. 2012–2018 Studium Biomolecular Engineering an der TU Darmstadt. Seit 2020 Promotion am Fachbereich Biologie der TU Darmstadt im Labor von PD Dr. J. Weigand.
Julia E. Weigand 2000–2005 Biologiestudium an der Universität Erlangen-Nürnberg. 2006–2009 Promotion im Labor von Prof. Dr. B. Suess an der Universität Erlangen-Nürnberg und der Universität Frankfurt a. M. 2010–2011 Postdoktorandin im Labor von Prof. Dr. S. Dimmeler an der Universität Frankfurt a. M. Seit 2012 Gruppenleiterin am Fachbereich Biologie der TU Darmstadt. 2020 Habilitation in Molekularbiologie, TU Darmstadt.
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