Table 1.
Gum Powder Type | Binder Type | D10 (μm) | D50 (μm) | D90 (μm) | Span |
---|---|---|---|---|---|
Fine GG | 25.0 ± 0.1 e | 56.7 ± 0.1 e | 108.9 ± 0.5 d | 1.48 ± 0.01 d | |
GG agglomerate | Glucose | 49.4 ± 0.1 c | 93.9 ± 0.1 c (39) | 179.4 ± 0.3 c | 1.39 ± 2·10−3 e |
Sucrose | 41.6 ± 0.1 d | 89.5 ± 0.4 d (58) | 179.4 ± 1.1 c | 1.54 ± 5·10−3 c | |
Lactose | 53.7 ± 0.4 b | 169.8 ± 0.4 a (200) | 445.7 ± 1.4 a | 2.31 ± 0.01 a | |
Sorbitol | 56.3 ± 0.5 a | 124.4 ± 0.4 b (117) | 293.0 ± 1.2 b | 1.90 ± 0.01 b | |
Fine LBG | 33.1 ± 0.1 e | 106.3 ± 0.1 d | 203.1 ± 0.1 e | 1.60 ± 1·10−3 a | |
LBG agglomerate | Glucose | 78.7 ± 0.3 b | 143.3 ± 0.4 b (35) | 238.1 ± 0.1 c | 1.11 ± 3·10−3 d |
Sucrose | 68.5 ± 0.1 d | 135.0 ± 0.2 c (27) | 233.2 ± 0.2 d | 1.22 ± 2·10−3 c | |
Lactose | 73.4 ± 0.3 c | 142.0 ± 0.7 b (34) | 246.9 ± 0.9 b | 1.22 ± 0.01 c | |
Sorbitol | 86.4 ± 0.3 a | 170.5 ± 0.3 a (61) | 310.8 ± 0.9 a | 1.32 ± 4·10−3 b | |
Fine CMC | 26.6 ± 0.1 d | 82.5 ± 0.1 d | 222.2 ± 0.6 d | 2.37 ± 5·10−3 a | |
CMC agglomerate | Glucose | 99.7 ± 0.5 a | 217.5 ± 1.2 a (163) | 400.4 ± 0.1 b | 1.38 ± 0.01 d |
Sucrose | 87.3 ± 0.2 c | 215.7 ± 0.6 b (159) | 408.4 ± 1.2 a | 1.50 ± 0.01 b | |
Lactose | 90.2 ± 0.5 b | 206.6 ± 1.5 c (151) | 391.6 ± 1.9 c | 1.46 ± 4·10−3 c | |
Sorbitol | 99.0 ± 0.3 a | 218.3 ± 0.7 a (164) | 400.2 ± 0.9 b | 1.38 ± 5·10−3 d |
D10, D50, and D90 are values of the particle diameter at 10%, 50%, and 90% in the cumulative size distribution, respectively. Values are means of three measurements ± SD. Means with different lowercase letters (a–e) within each column are significantly different (p < 0.05). Percentage increase in D50 is between non-agglomerated and agglomerated gum powders.