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. 2021 Jun 16;26(12):3677. doi: 10.3390/molecules26123677

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of methiothepin (5-HT1/6/7 receptor antagonist), ketanserin (5-HT2A receptor antagonist), and ondansetron (5-HT3 receptor antagonist) pre-treatment on cardamonin against mechanical allodynia of CCI-induced neuropathic pain mice were evaluated using von-Frey filament test. Data were presented as mean ± SEM (n = 6). The caret, hash, and asterisks denote the significance levels (one-way ANOVA, followed by Tukey’s post hoc test, ^{^^} p < 0.01, ^{^^^} p < 0.001 as compared to sham, ^### p < 0.001 as compared to vehicle and *** p < 0.001, **** p < 0.001 as compared to cardamonin-treated group. SHM (Sham); VEH (Vehicle, 10 mL/kg i.p.); C (Cardamonin, 10 mg/kg i.p.); MET (Methiothepin, 0.1 mg/kg, i.p.); KET (Ketanserin, 0.3 mg/kg, i.p.); OND (Ondansetron, 0.5 mg/kg, i.p.).