Skip to main content
Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2021 May 20:ciab465. doi: 10.1093/cid/ciab465

Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Alana F Ogata 1,2,3,#, Chi-An Cheng 1,2,3,#, Michaël Desjardins 3,4,5,#, Yasmeen Senussi 1, Amy C Sherman 3,4, Megan Powell 4, Lewis Novack 4, Salena Von 4, Xiaofang Li 6, Lindsey R Baden 3,4,6,#, David R Walt 1,2,3,#,
PMCID: PMC8241425  PMID: 34015087

Abstract

SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.

Keywords: COVID-19, mRNA vaccine, SARS-CoV-2 antigens, immune responses, spike

Supplementary Material

ciab465_suppl_Supplementary_Materials

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

ciab465_suppl_Supplementary_Materials

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

RESOURCES