Clinical Outcome Evaluation of Anatomic Anterior Cruciate Ligament Reconstruction With Tunnel Positioning Using Gold Standard Techniques: A Systematic Review and Meta-analysis

Abstract

Background:

There have been conflicting results about the theoretical advantages of anatomic double-bundle anterior cruciate ligament (ACL) reconstruction.

Purpose:

To evaluate the clinical and functional outcomes comparing anatomic single- versus double-bundle techniques, anatomic versus nonanatomic techniques, and transportal versus outside-in tunnel drilling for ACL reconstruction.

Study Design:

Systematic review; Level of evidence, 3.

Methods:

A search was performed in the MEDLINE and EMBASE databases up to August 2018 for clinical trials comparing anatomic ACL reconstruction (with tunnel positioning demonstrated using gold standard radiologic techniques) with another technique, with a minimum functional and biomechanical follow-up of 6 months. A meta-analysis was performed to compare clinical and functional outcomes between anatomic single- versus double-bundle reconstruction and between anatomic versus nonanatomic techniques, using the risk difference or the mean difference. Risk of bias of the included studies was assessed using the Newcastle-Ottawa Scale for cohort and case-control studies and the Cochrane Risk of Bias tool and Jadad Score for randomized controlled trials.

Results:

Included were 15 studies comprising 1290 patients (follow-up, 12-36 months). No significant differences favoring anatomic double-bundle over anatomic single-bundle reconstruction or outside-in over transportal techniques were found. The meta-analyses showed significant differences in the International Knee Documentation Committee (IKDC) objective score (risk difference, –0.14; 95% confidence interval, –0.27 to –0.01) favoring anatomic over nonanatomic reconstruction. No statistically significant differences were found between anatomic and nonanatomic surgical techniques on other functional scores or clinical examination outcomes, including the IKDC subjective score, Lysholm score, Tegner score, KT-1000 arthrometer test, or pivot-shift test.

Conclusion:

Double-bundle reconstruction was not superior to the single-bundle technique in clinical and functional outcomes. Anatomic ACL reconstruction shows significantly superior results over nonanatomic ACL reconstruction, reinforcing the anatomic technique as the gold standard choice for clinical practice.

The standard technique for anterior cruciate ligament (ACL) reconstruction is the arthroscopic single-bundle reconstruction using autografts. ^23,41 There has been a growing interest in an anatomic approach to ACL reconstruction ^8,45 that aims to replicate the native knee anatomy and restore knee kinematics while protecting the knee from further injuries or the onset of knee osteoarthritis. Cadaveric studies have shown benefits of using anatomic ACL reconstruction on restoring sagittal and rotational stability and improving knee function. ^22,28

Anatomic ACL reconstruction mainly consists of functional restoration of the ACL to its native dimensions, collagen orientation, and insertion sites, positioning tunnels in the ACL footprint, which has 2 distinct portions or “bundles”: an anteromedial bundle and a posterolateral bundle. ^41,44 The anteromedial bundle is the primary restraint against anterior tibial translation, with more knee flexion, while the posterolateral bundle secures the knee when near full extension, particularly against rotational loads. ⁴¹

However, use of the term “anatomic” with regard to ACL reconstruction can be misleading, as it has been used interchangeably with several ACL reconstruction techniques. ³ A systematic review of cadaveric studies by van Eck et al ⁴⁵ has found that the anatomic ACL reconstruction was poorly defined and there is a gross underreporting of the surgical technique methods; thus, to be considered anatomic, the ACL reconstruction tunnels must be positioned in the center of the femoral and tibial footprints. Only two-thirds of studies visualized the tibial and femoral ACL insertion sites, and none had measured the insertion sites or visualized the bony ridges. ⁴⁵ Studies reporting anatomic ACL reconstruction in adult human patients have shown heterogeneity and underreporting of the ACL insertion site and femoral intercondylar notch measurement, individualization of surgery, knee flexion angle during femoral tunnel drilling, graft tensioning pattern, and intraoperative/postoperative imaging. ⁴⁷

Correct characterization of the insertion site anatomy in ACL reconstruction with precise radiologic methods, such as computed tomography (CT) or magnetic resonance imaging (MRI) evaluating the 3 axes, can be performed with high intra- and interobserver reliability and small standard errors of measurement. ⁷ However, despite the development of contemporary techniques and experienced orthopaedic surgeons, positioning of the femoral tunnel is often imprecise. ¹⁰

The purpose of this systematic review was to compare the outcomes of anatomic single-bundle (ASB) versus anatomic double-bundle (ADB) ACL reconstruction with tunnel positioning demonstrated using gold standard radiologic techniques. As a secondary objective, we aimed to compare anatomic versus nonanatomic techniques and transportal to outside-in tunnel drilling in anatomic ACL reconstruction. The hypothesis was that ADB reconstruction would result in superior clinical outcomes over nonanatomic or ASB reconstruction techniques.

Methods

Protocol and Registration

This systematic review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. ¹³ The review was a priori registered at the international prospective register of systematic reviews (PROSPERO; identification No. CRD42016042603).

Search Strategy

A comprehensive database search using the MEDLINE and EMBASE was conducted on August 28, 2018. The following search terms were used: “anterior cruciate ligament” OR “ACL” AND “anatomic” OR “anatomical” AND “reconstruction” OR “surgery.” The reference lists of the selected studies and other relevant studies were screened to identify potential additional studies that were not found through the electronic search.

Study Selection

All titles and abstracts were screened, and the full text of all potentially relevant studies identified was retrieved and analyzed according to the following inclusion criteria: (1) prospective or retrospective cohort studies, (2) studies comparing anatomic with nonanatomic reconstruction or ASB to ADB reconstruction techniques, (3) minimum functional and biomechanical postoperative evaluation of 6 months, and (4) tunnel positioning demonstrated using gold standard radiologic techniques. For inclusion purposes, “anatomic ACL reconstruction” was defined as the identification and insertion of the femoral tunnel at the ACL native footprint. The population of interest was skeletally mature patients with documented ACL deficiency of the knee, requiring arthroscopically assisted ACL reconstruction. All arthroscopic tunnel drilling techniques were included, as well as any method of fixation of the graft. Excluded were studies without confirmation of tunnel positioning using MRI or CT scan, ACL reconstruction using allografts or synthetic materials, and ACL revision surgeries.

Titles and abstracts were reviewed by 2 independent authors (T.L.F., S.U.S.), who applied the eligibility criteria and retrieved the full text of potential articles to be included. If the abstract did not provide enough data to make an immediate decision, the full text was also retrieved. The same 2 independent authors analyzed the full texts using the previously described criteria. Any disagreement between the 2 reviewers was resolved via consensus.

Data Collection Process

Data were extracted according to a predefined standardized data sheet. The same independent authors compared the data extracted for each study to achieve consensus.

Continuous outcomes were extracted as mean and standard deviation and included the following parameters. Because ACL reconstruction is usually an operation performed in active patients, we evaluated return to activity/level of sports participation, including Tegner and Lysholm scores ⁴² and clinical composite scores of the International Knee Documentation Committee (IKDC) subjective knee form. ¹⁵ The static stability measures (KT arthrometer or other stability assessment devices, including stress tests and an open MRI or 3-dimensional CT scan).

Categorical outcomes were collected as the total number of events for clinical composite scores (IKDC objective knee form) ¹⁵ and clinical stability examination (pivot-shift test). The IKDC objective scores were defined as positive (if rated A or B) or negative (if rated C or D). Pivot shift of the operated knee was compared with that of the contralateral knee and was graded as 0 (no laxity) to 3 (maximum laxity). An event was defined as positive (if rated 0 or 1) or negative (if rated 2 or 3).

Outcome assessment was analyzed based on a minimum 6-month postsurgical state, and measurements obtained at time zero (intraoperatively) were excluded.

Methodological Quality and Risk of Bias in Individual Studies

The methodological quality of cohort and case-control studies was appraised using the Newcastle-Ottawa Scale (NOS), which judges studies on 8 items, divided into 3 groups: the selection of the study groups, the comparability of the groups, and the ascertainment of either the exposure or the outcome of interest. Stars are given for the evaluated items, up to a maximum of 9, with 7 being the cutoff point for high-quality studies. ²⁶

The risk of bias of randomized trials was evaluated using the Cochrane Collaboration Risk of Bias tool ¹¹ and the Jadad scale. ¹⁶ The Risk of Bias tool evaluated the following domains of bias as high or low risk: focal question, random sequence generation, allocation concealment, blinding, completeness of outcome data, demographic aspect, outcomes, intention to treat, and sample calculation. The quality of the study was based on the sum of the risks assessed in each domain. A study with a single domain with a high risk of bias was considered to be moderate quality, and a study having >1 domain was considered to be low quality. The Jadad scale is a procedure to independently assess the methodological quality of a clinical trial, judging the effectiveness of blinding and scoring between 0 (very poor) and 5 (rigorous). Two review authors (T.L.F., S.U.S.) independently scored the methodological quality of included studies. Any disagreements were resolved via consensus.

Quantitative Synthesis

Data were extracted on an intention-to-treat basis. The level of statistical significance was set at a P value <.05. The differences between the outcome measures using the risk difference for dichotomous variables and the mean difference for continuous variables with a 95% confidence interval were calculated. Data were analyzed using Review Manager software Version 5.3 (RevMan 5.3; Cochrane Collaboration), using the Mantel-Haenszel method for categorical variables and the inverse variance method for continuous variables. Fixed and random effects based on the heterogeneity statistic I² were considered, and a cutoff point of 50% was used. When an I² ≥50% was found, a sensitivity analysis was performed to identify any studies with a higher probability of a publication bias (outliers), using a funnel plot with a fixed-effects model. The objective of the sensitivity analysis was to identify publication bias that explains the heterogeneity observed using the Egger test (funnel plot). When there was no publication bias, a random-effects model was used for the analysis. To further investigate heterogeneity, subgroup analyses were performed according to the type of study design of the studies. In the conflict between randomized controlled trials (RCTs) and cohort studies, the results of RCTs were considered.

Results

Study and Population Characteristics

From the initial 2755 articles found in the literature search, 15 studies, all published between 2011 and 2018, were included in this systematic review (Figure 1). ^∥∥ A total of 1290 patients were followed for a period between 12 and 36 months after surgery. The characteristics of participants comparing ASB versus ADB, anatomic versus nonanatomic, and transportal versus outside-in are presented in Tables 1 to 3, respectively. There were no apparent statistically significant differences in characteristics between the different surgical techniques.

Figure 1.

Flowchart of literature search process using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. CT, computed tomography; MRI, magnetic resonance imaging.

Table 1.

Characteristics of Studies on Anatomic Single- Versus Double-Bundle ACL Reconstruction ^a

Study (Year)	Anatomic Single-Bundle			Anatomic Double-Bundle
	No. of Patients	Age, y	Male/Female	No. of Patients	Age, y	Male/Female
Aga (2018) 1	62	27.1 ± 5.5	41/21	54	27.4 ± 6.3	47/7
Hussein (2012) 12	30	28.1	NR	64	26	NR
Sadoghi (2011) 32	17	NR	NR	16	NR	NR
Suomalainen (2013) 38	25	30 ± 8	18/7	25	32 ± 11	16/9
Taketomi (2014) 39	26	26	24/2	26	31	14/12
Xu (2013) 47	32	33.3 ± 12.8	25/7	34	30.2 ± 7.7	24/10
Zhang (2016) 50	20	22.3 ± 5.3	13/7	20	28.3 ± 6.1	14/6

^a Data are presented as number of patients or mean ± SD. ACL, anterior cruciate ligament; NR, not reported.

Table 2.

Characteristics of Studies on Nonanatomic Versus Anatomic Techniques ^a

	Nonanatomic			Anatomic
Study (Year)	No. of Patients	Age, y	Male/Female	No. of Patients	Age, y	Male/Female
Lee (2014) 20	52	NR	NR	52	NR	NR
Pande (2017) 30	49	29.35 ± 7.95	47/2	43	31.16 ± 7.73	41/2
Sadoghi (2011) 32	33	NR	NR	20	NR	NR
Seo (2013) 33	41	30.6 ± 11.14	32/9	48	32.4 ± 13.3	40/8
Sukur (2016) 36	49	26.8 ± 5.7	45/4	56	25.5 ± 5	52/4
Tashiro (2017) 40	20	29 ± 9	NR	30	27 ± 9	NR
Youm (2014) 49	20	29.7 ± 11.9	20/0	20	27.6 ± 9.9	19/1

^a Data are presented as number of patients or mean ± SD. NR, not reported.

Table 3.

Aspects Comparing the Groups Undergoing the Transportal Versus Outside-In Technique ^a

Study (Year)	Transportal			Outside-In
	No. of Patients	Age, y	Male/Female	No. of Patients	Age, y	Male/Female
Kim (2018) 18	53	36.4 ± 10.1	40/13	58	35 ± 10.1	51/7
Sim (2018) 35	32	23.9 ± 0.2	27/5	32	24.8 ± 8	23/9

^a Data are presented as number of patients or mean ± SD.

ASB Versus ADB ACL Reconstruction

There were 7 studies with 451 patients on ASB versus ADB, with 212 patients undergoing ASB and 239 undergoing ADB reconstruction (Table 1). ^{1,12,32,38,39,47,50} The postoperative assessment ranged between 12 months ^32,39,50 and 30 months. ¹² Meta-analysis showed no statistically significant differences on all outcomes evaluated: Tegner score (3 studies ^32,47,50 ; 139 patients), Lysholm score (5 studies ^{12,38,39,47,50} ; 294 patients), IKDC objective (3 studies ^12,32,38 ; 169 patients) and subjective (4 studies ^12,32,47,50 ; 233 patients) scores, pivot-shift test (6 studies ^{1,12,32,38,39,47} ; 400 patients), and KT-1000 arthrometer test (7 studies ^{1,12,32,38,39,47,50} ; 440 patients). Forest plots are available online as Supplementary Material (Supplemental Figures S1-S6).

Anatomic Versus Nonanatomic ACL Reconstruction

Seven studies compared anatomic with nonanatomic ACL reconstruction, with 269 patients having the anatomic technique and 264 undergoing the nonanatomic technique (Table 2). Three studies ^32,33,40 had a minimum 12-month follow-up, while the other 4 studies ^20,30,36,49 were at least 24 months. The meta-analysis showed statistically significant differences in the IKDC objective score favoring the anatomic reconstruction (risk difference, –0.14; 95% confidence interval, –0.27 to –0.01) (Figure 2). Sadoghi ³² evaluated two groups, and made comparisons between anatomical versus non-anatomical reconstruction using both the bone-patellar tendon-bone graft and the semitendinous-gracilis graft technique. As only Sadoghi et al ³² and Youm et al ⁴⁹ evaluated this outcome, the result is because of the samples from the cohort studies, whereas the RCT ⁴⁹ did not show a statistically significant difference. No statistically significant superiority was found between the anatomic and nonanatomic surgical techniques for other functional scores or physical examination, including the IKDC subjective score (4 studies ^20,30,32,50 ; 289 patients), KT-1000 arthrometer test (4 studies ^20,32,33,40 ; 296 patients), Lysholm score (5 studies ^{20,30,33,40,49} ; 375 patients), Tegner score (5 studies ^{20,30,32,33,49} ; 378 patients), and pivot-shift test (5 studies ^{20,32,33,36,49} ; 395 patients). Forest plots are available as supplementary material (Supplemental Figures S7-S11).

Figure 2.

Meta-analysis of nonanatomic versus anatomic anterior cruciate ligament (ACL) reconstruction evaluating the International Knee Documentation Committee (IKDC) objective score. The results indicated a significant difference in favor of anatomic reconstruction. M-H, Mantel-Haenszel; OBJ, objective; RCT, randomized controlled trial.

Transportal Versus Outside-In Tunneling

Two studies ^18,35 compared transportal to outside-in tunneling, totaling 85 patients having the transportal technique and 90 patients undergoing the outside-in technique (Table 3). Both studies performed anatomic ACL reconstruction; however, Sim et al ³⁵ used the ASB technique, and Kim et al ¹⁸ used the ADB technique. No statistically significant differences were found between tunneling techniques for the IKDC subjective score, Tegner score, or pivot-shift test (2 studies ^18,35 ; 175 patients). Forest plots are available online as Supplementary Material (Supplemental Figures S12-S14).

Risk of Bias

The risk of bias of RCTs was evaluated using the Cochrane Collaboration Risk of Bias tool, and 1 study was considered low quality ⁴⁰ ; 1, moderate ⁴⁷ ; and the other 3, high quality. ^1,18,49 The domain with a higher risk of bias was blinding (high risk in 3 studies) because of the nonblinding of outcome assessors. When the Jadad scale was applied to the articles, the average score was 3.2 points out of 5 possible (Table 4).

Table 4.

Risk-of-Bias Assessment for RCTs: Cochrane Tool, Jadad Scale ^a

	Cochrane Risk-of-Bias Tool: Scale Item a
Study (Year)	1	2	3	4	5	6	7	8	9	Jadad Score
Aga (2018) 1	Low	Low	Low	Low	Low (2.5%)	Low	Low	Low	Low	5
Tashiro (2017) 40	Low	High	High	High	Low (20%)	Low	Low	Low	High	0
Youm (2014) 49	Low	Low	Low	Low	Low (0%)	Low	Low	Low	Low	5
Xu (2013) 47	Low	Low	High	High	Low (17.5%)	Low	Low	Low	High	3
Kim (2018) 18	Low	Low	Low	High	Low (7.8%)	Low	Low	Low	Low	3

^a Items: 1 = focal question; 2 = random sequence generation; 3 = allocation concealment; 4 = blinding; 5 = completeness of outcome data (<20% lost); 6 = demographic or prognostic characteristics; 7 = outcomes; 8 = intention to treat; 9 = sample calculation; RCT, randomized controlled trial.

The methodological quality of nonrandomized (cohort and case-control) studies evaluated using NOS was high (mean NOS score, 7.6), with 6 studies ^{12,20,30,33,36,38} considered high quality (NOS = 8)  and 4 studies ^32,35,39,50 considered moderate quality (NOS = 7) (Table 5).

Table 5.

Risk-of-Bias Assessment for Cohort and Case-Control Studies: Newcastle-Ottawa Scale ^a

	Selection Bias				Comparability	Outcome/Exposure
Study (Year)	1	2	3	4	1	1	2	3
Pande (2017) 30		*	*	*	**	*	*	*
Sukur (2016) 36		*	*	*	**	*	*	*
Lee (2014) 20		*	*	*	**	*	*	*
Sim (2018) 35		*	*	*	**	*	<24 mo	*
Zhang (2016) 50		*	*	*	**	*	<24 mo	*
Sadoghi (2011) 32		*	*	*	**	*	<24 mo	*
Seo (2013) 33		*	*	*	**	*	*	*
Hussein (2012) 12		*	*	*	**	*	*	*
Suomalainen (2013) 38		*	*	*	**	*	*	*
Taketomi (2014) 39		*	*	*	**	*	<24 mo	*

^a In this scale, each item is scored either 0 or 1 stars, except for comparability, which can score 0, 1, or 2 stars, totaling 9 stars.

Discussion

The main finding of this study was that there was significant superiority in the IKDC objective score of anatomic compared with nonanatomic ACL reconstruction; however, ADB reconstruction was not superior to ASB reconstruction, and the outside-in technique was not superior to the transportal tunnel drilling technique in any of the clinical and functional outcomes assessed.

Anatomic ACL reconstruction presents theoretical advantages despite many patients reporting some residual knee instability, not returning to their previous level of sports activity, and the development of knee degenerative changes. ^2,21,37 The anatomic reconstruction aims to restore knee anatomy and kinematics as close as possible and places the graft more horizontal to better control the rotational laxity. ⁴ The anatomic placement of the graft reduces the risk of impingement at the intercondylar notch, loss of range of motion, and failure of the fixation or the graft itself, which may cause suboptimal results. ²⁹ Yasuda et al ⁴⁸ showed significantly better results in patients operatively treated using anatomic reconstruction regarding side-to-side anterior laxity; these results were subsequently corroborated in laboratory studies, restoring the uninjured knee to levels of stability. ⁹ In our systematic review, we found a significant superiority of anatomic over nonanatomic ACL reconstruction in the IKDC objective score but not in other clinical and functional outcomes.

The potential superiority of ADB has been debated in the literature within the past decade. The main advantages of ADB reconstruction are that ADB better re-creates the double-bundle native ACL anatomy and knee kinematics and provides better control of postoperative knee stability. ²⁴ Despite these advantages, there are some indications that the ASB technique should be performed instead of the double-bundle technique: tibial insertion site <14 mm in length (measured arthroscopically), concomitant arthritic changes (Kellgren-Lawrence grade ≥3), knee multiligament injury, severe bone bruising, open physes, and a narrow and/or shallow intercondylar notch (<14 mm each). ^14,34,44 When the posterior bundle is reconstructed, there is theoretical benefit of improved rotational stability, but recent studies have indicated that despite requiring more surgical time and greater technical difficulty, ⁶ ADB ACL reconstruction does not result in superior clinical and functional outcomes compared with ASB ACL reconstruction (when grafts are placed at the center of the anatomic position and the femoral tunnel is lower than it is when the standard technique is used). ^17,24,27

In the present systematic review, there was no significant superiority of the ASB or ADB technique over the other. A considerable amount of research has been published in the past few decades comparing ADB with ASB ACL reconstruction techniques, and other systematic reviews have been published on this topic. A systematic review reported that ADB reconstruction can eliminate pathologic findings in the pivot-shift test, ⁴⁹ which was not corroborated in the present meta-analysis. Mascarenhas et al ²⁴ performed a systematic review overlapping 9 meta-analyses and found that the ADB technique resulted in superior KT-1000 arthrometer and pivot-shift test outcomes. Similarly, a meta-analysis performed by Xu et al ⁴⁷ found that the ADB technique resulted in superior pivot-shift tests and IKDC objective scores. The meta-analysis by Björnsson et al ³ did not show superiority of the technique in clinical evaluation at short- and long-term follow-ups, such as the preoperative level and performance of return to sports activity. In a meta-analysis, van Eck et al ⁴³ presented positive results for double-bundle reconstruction for anterior and rotational laxity, assessed using arthrometer and physical examination (Lachman and pivot-shift tests), while Mundi and Bhandari ²⁷ showed faster return to the sports and a reduced risk of new ACL injuries. However, even when the comparison between ADB and ASB techniques showed significant differences in prospective studies, they were limited to objective evaluations because in the postoperative period, patients had similar opinions regardless of the surgical technique, as exemplified in the study by Kondo et al ¹⁹ according to Massey et al, ²⁵ in which the patients had superior results in ADB reconstruction via the KT-2000 arthrometer but no statistically different scores, such as the IKDC subjective. We must consider that physical and noninstrumented examination is highly subjective and can present great variation among examiners. Despite all the theoretical advantages of the ADB technique, the literature has shown inconsistent results, and there is no convincing and consistent evidence that ADB would be superior to ASB ACL reconstruction, which is underpinned by the present study.

The transportal and outside-in femoral drilling techniques are both able to obtain an anatomic graft placement. The transportal technique allows one to perform the ACL reconstruction all-inside but has the risk of posterior wall blowout. In turn, the outside-in technique prevents the risk of posterior wall blowout but requires increased operative time and a second incision that can lead to further morbidity. ^14,31 Recently, researchers have questioned if there are differences in the functional results of these 2 techniques because the graft is placed at a sharper angle when using outside-in drilling, which may increase the stress to which it is submitted. ¹⁸ Although Kim et al ¹⁸ found a difference in the IKDC objective score favoring the outside-in technique, no significant differences for functional, clinical, and imaging postoperative outcomes have been reported. ^5,18 The present meta-analysis corroborates the finding that there are no significant differences between transportal and outside-in techniques.

The results of this systematic review and meta-analysis are relevant for the clinical practice, as they reinforce anatomic ACL reconstruction as standard of care, using only studies that demonstrated the graft placement using gold standard radiologic imaging techniques. When comparing outcomes of ACL reconstruction techniques, it is important to have confirmation of the tunnel positions to ensure that the comparison is valid. No recommendation can be made on the choice between ADB or ASB technique and transportal or outside-in femoral drilling, as there were no statistically significant differences, and which technique is superior remains elusive. The choice of technique should thus be guided based on surgeon experience, available equipment, patient characteristics, and graft choice. ¹⁴

There are some limitations in the present study. The small number of published randomized clinical trials comparing anatomic reconstruction verified using gold standard postoperative imaging using different techniques limited the robustness of the meta-analyses. In addition, the follow-up was short in some studies, and there was no discrimination regarding the specific sport or level of competition of the patients. More high-quality studies using gold standard tunnel positioning evaluation methods are warranted to confirm the robustness of the results because even in ADB ACL reconstruction, making 2 tunnels in the femur and tibia does not necessarily guarantee that they are in the proper position to consider the anatomic technique. ⁴⁶

Conclusion

The current systematic review demonstrated that there were no significant differences in functional or clinical outcomes comparing ASB versus ADB ACL reconstruction and comparing transportal versus outside-in femoral drilling. Anatomic ACL reconstruction had a significant superior IKDC objective score compared with nonanatomic ACL reconstruction, but other functional and clinical outcomes showed no significant differences.