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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2021 May 29:ciab492. doi: 10.1093/cid/ciab492

Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers

Stéphane Marot 1,, Isabelle Malet 1, Valentin Leducq 1, Basma Abdi 1, Elisa Teyssou 1, Cathia Soulie 1, Marc Wirden 1, Christophe Rodriguez 2,3, Slim Fourati 2,3, Jean-Michel Pawlotsky 2,3, David Boutolleau 1, Sonia Burrel 1, Vincent Calvez 1, Anne-Geneviève Marcelin 1, Aude Jary 1
PMCID: PMC8244299  PMID: 34050731

Abstract

There are concerns about neutralizing antibodies (NAbs) potency against SARS-CoV-2 variants. Despite decreased NAb titers elicited by BNT162b2-vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCW) had a NAb titer ≥1:10. In contrast, six months after COVID-19 mild-forms, only 9/15 (60%) of HCW displayed detectable NAbs against 501Y.V2 strain.

Keywords: COVID-19, Vaccine, Neutralizing antibodies, SARS-CoV-2 variants

Supplementary Material

ciab492_suppl_Supplementary_Table_S1

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

ciab492_suppl_Supplementary_Table_S1

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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