Figure 7.

Unique differentially expressed proteins

Box-and-whisker plots of differentially expressed individual proteins that displayed a significantly different abundance (q < 0.05) in the prediabetic or T2D samples compared with the NGT samples. Box-and-whisker plots indicate median and interquartile range; the whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box. ATP-dependent RNA helicase SUPV3L1 protein expression was uniquely reduced in IFG muscles. Small nuclear ribonucleoprotein-associated protein N (SNRPN) expression was uniquely downregulated in IGT muscles. ATP synthase subunit a (MT-ATP6), NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (NDUFAF6) and tubulin-folding cofactor B (TBCB) were significantly downregulated only in T2D muscles. ∗ = q < 0.05; ∗∗ = q < 0.01, ns = nonsignificant differences, one-way ANOVA followed by Dunnett's post hoc test with the NGT group as the reference group.