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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Cell. 2020 Jan 30;180(4):645–654.e13. doi: 10.1016/j.cell.2020.01.007

Figure 2. WIN 55,212–2 Binding in CB2 Orthosteric Ligand-Binding Site.

Figure 2.

(A) The overview of CB2 in complex with WIN 55,212–2. Cyan sphere model: chemical structure of WIN 55,212–2. Magenta cartoon: cryo-EM structure of CB2.

(B) Detailed interactions of WIN 55,212–2 (cyan) within CB2 (magenta). The residues involved in the binding pocket of CB2 are mainly hydrophobic (magenta sticks) and are derived from TM2-TM3, TM5-TM7, and ECL2.