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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Cell. 2020 Jan 30;180(4):645–654.e13. doi: 10.1016/j.cell.2020.01.007

Figure 6. Comparison of Docking Results of CB2 Selective Partial Agonist GW-405,833 (L-768,242) on Active CB2 and Inactive CB1.

Figure 6.

(A) Comparison of docking poses and detailed interactions of CB2 selective partial agonist GW-405,833 on active CB2 (magenta) and inactive CB1 (gray, PDB: 5TGZ). It is reported that GW-405,833 acts as CB2 agonist (Ki=3.92 ± 1.58 nM) and CB1 antagonist (Ki=4772 ± 1676 nM).

(B) Comparison of residual energy contribution on GW-405,833 between active CB2 (magenta bars) and inactive CB1 conformations (gray bars).